微小RNA与急性缺血性卒中的关系研究进展

Advances in the relationship between microRNA and acute ischemic stroke

众所周知,急性缺血性卒中发病率高、致残率高,病生理过程复杂,伴有神经细胞氧化应激、缺血再灌注损伤、炎症反应、血流改变、血脑屏障的破坏、细胞凋亡、钙稳态的破坏等一系列变化,最终导致神经细胞和突触的变化;近年的研究发现,中枢神经系统存在大量微小RNA(miRNA),小分子、短序列、非编码miRNA分子显示重要的基因表达的转录调节,并参与这一病理生理过程。本文描述了微小RNA与缺血性脑卒中危险因素的关系,在缺血性卒中发生以及缺血性卒中后神经保护、生物再生中的作用,并对其应用于缺血性卒中的治疗前景及缺陷给予了阐述。

It is well known that the incidence and disability rate of acute ischemic stroke are high,the physiological processes are complicated,accompanied a series of changes with oxidative stress of nerve cells, ischemia-reperfusion injury, inflammatory reaction, blood flow change, destruction of blood-brain barrier,poptosis,disruption of calcium homeostasis and so on,which eventually result the changes of nerve cells and synapses. In recent years,the study found that there are lots of microRNA（miRNA） in the central nervous system,small molecules,short sequences and non encoding miRNA molecules display transcriptional regulation of important genes expression, and participate in the pathophysiologic process. This paper describes the relationship between miRNA and ischemic stroke risk factors,the role of neuroprotection and biological regeneration when ischemic stroke occur and after ischemic stroke. The treatment prospects and defects of ischemic stroke are also discussed.