左乙拉西坦联合奥卡西平治疗小儿癫痫的疗效及安全性

Efficacy and Safety of Levetiracetam Combined with Oxcarbazepine in Treatment of Children with Epilepsy

目的:探讨左乙拉西坦联合奥卡西平治疗小儿癫痫的疗效及安全性。方法:选取2015年6月—2016年8月南昌大学第一附属医院收治的癫痫患儿88例作为研究对象,以随机数字表法分为观察组和对照组,每组44例。对照组患儿给予奥卡西平治疗,观察组患儿在对照组的基础上加用左乙拉西坦治疗。观察两组患儿的癫痫发作、脑电图改善及不良反应发生情况。结果:观察组患儿的癫痫发作总有效率为97.73%(43/44),明显高于对照组的86.36%(38/44);观察组患儿的脑电图改善总有效率为95.45%(42/44),明显高于对照组的77.27%(34/44);观察组患儿不良反应发生率明显低于对照组,差异均有统计学意义(P<0.05)。结论:左乙拉西坦联合奥卡西平治疗小儿癫痫的疗效显著,明显改善了患儿灰质痫样放电,且安全性较高。

OBJECTIVE： To probe into the efficacy and safety of levetiracetam combined with oxcarbazepine in treatment of children with epilepsy. METHODS： 88 children with epilepsy admitted into the First Affiliated Hospital of Nanchang University from Jun. 2015 to Aug. 2016 were selected to be divided into observation group and control group via the random number table,with 44 cases in each. The control group was given oxcarbazepine,while the observation group additionally received levetiracetam based on the control group. The epilepsy,improvement of electroencephalogram（ EEG） and incidence of adverse drug reactions in two groups were observed. RESULTS： The total effective rate of epilepsy in observation group was 97. 73%（ 43/44）,significantly higher than that in control group [86. 36%（ 38/44） ];the total effective rate of improvement of EEG in observation group was 95. 45%（ 42/44）,significantly higher than that in control group [77. 27%（ 34/44） ]; the incidence of adverse drug reactions of observation group was significantly lower than that of control group,with statistically significant difference（ P〈0. 05）. CONCLUSIONS： The efficacy of levetiracetam combined with oxcarbazepine in treatment of children with epilepsy is remarkable,which can effectively improve the gray epileptiform discharge with high safety.