吡柔比星膀胱内灌注联合经尿道电切术治疗腺性膀胱炎的疗效观察

Observation on Efficacy of Intravesical Perfusion with Perarubicin Combined with Transurethral Electronic Incision in Treatment of Cystitis Glandularis

目的:探讨吡柔比星膀胱内灌注联合经尿道电切术治疗腺性膀胱炎的疗效。方法:选择2014年12月—2016年12月收治的腺性膀胱炎患者84例作为研究对象,按随机数字表法分成观察组和对照组,每组42例。对照组患者行经尿道电切术,观察组患者在对照组基础上应用吡柔比星膀胱内灌注,比较两组患者的疗效,白细胞介素2(IL-2)、干扰素γ(IFN-γ)、肿瘤坏死因子α(TNF-α)水平变化情况及不良反应发生情况。结果:治疗后,观察组患者的总有效率90.48%(38/42),对照组为73.81%(31/42),两组的差异有统计学意义(P<0.05)。治疗后,两组患者IL-2、IFN-γ、TNF-α均较治疗前明显改善,且观察组患者改善情况明显优于对照组,差异均有统计学意义(P<0.05)。观察组患者的不良反应发生率为14.29%(6/42),明显低于对照组的33.33%(14/42),差异有统计学意义(P<0.05)。结论:吡柔比星膀胱内灌注联合经尿道电切术治疗腺性膀胱炎的效果较好,可调节患者免疫功能,安全性较高。

OBJECTIVE： To probe into the efficacy of intravesical perfusion with perarubicin combined with transurethral electronic incision in treatment of cystitis glandularis. METHODS： 84 patients with cystitis glandularis admitted from Dec. 2014 to Dec. 2016 were extracted to be divided into observation group and control group via the random number table,with 42 cases in each. The control group was treated with transurethral electronic incision,while the observation group additionally received intravesical perfusion based on the control group. The efficacy,changes of IL-2,IFN-γ,TNF-α level and incidence of adverse drug reactions of two groups were compared. RESULTS： After treatment,the total effective rate of observation group was 90. 48%（ 38/42）,while the control group was 73. 81%（ 31/42）,the difference was statistically significant（ P〈0. 05）. After treatment,the IL-2,IFN-γ,TNF-α level had been improved significantly compared with before treatment,and the observation group was better than the control group,with statistically significant difference（ P〈0. 05）. The incidence of adverse drug reactions was 14. 29%（ 6/42）,significantly lower than that of control group [33. 33%（ 14/42） ], with statistically significant difference（ P〈0. 05）.CONCLUSIONS： The efficacy of intravesical perfusion with perarubicin combined with transurethral electronic incision in treatment of cystitis glandularis is remarkable,which can regulate patient＇s immune function with high safety.