参芪花粉片联合化疗对于小细胞肺癌与非小细胞肺癌治疗的预后比较研究

Study of Shenqi pollen tablets combined with chemotherapy in treatment of small cell lung cancer and non-small cell lung cancer

目的对于参芪花粉片联合化疗对于小细胞肺癌与非小细胞肺癌治疗的预后比较分析。方法研究选取2014—2016年间就诊的确诊肺癌患者76例,分为参芪花粉片联合化疗治疗的观察组和仅使用化疗治疗的对照组进行研究分析。随访收集患者疗效以及预后信息,本研究主要分析讨论了随访3个月的短期预后情况,并进行比较讨论。统计分析使用SPSS 16.0统计软件包。结果 NSCLC患者中观察组的完全缓解率为3.33%,对照组未见完全缓解患者;与对照组比较,观察组的稳定病例比例高于对照组,观察组的进展病例所占比例显著低于对照组,P<0.01;此外两组总有效率比较也提示观察组高于对照组P<0.01。小细胞肺癌患者中观察组和对照组随访3个月的疗效情况与非小细胞肺癌患者相似。NSCLC患者的预后情况分析结果提示观察组的生活质量改善的比例为59.09%,高于对照组的45.45%,P<0.05;生活质量降低的比例则表现出低于对照组P<0.01;观察组3个月随访的复发率为4.55%,显著低于对照组,P<0.01。在小细胞肺癌患者中观察组的生活质量改善的比例高于对照组,P<0.01;而稳定的比例低于对照组,P<0.05。观察组3个月随访的转移率为12.50%,显著低于对照组,P<0.05。结论参芪花粉片联合化疗对于NSCLC和小细胞肺癌患者的短期预后生活质量改善均起到很好效果,特别是对于NSCLC患者更为明显;此外参芪花粉片联合化疗可以在一定程度上减低NSCLC患者复发率和小细胞肺癌患者的转移率。

Objective To compare the prognostic value of Shenqi pollen tablets combined with chemotherapy in the treatment of small cell lung cancer and non - small cell lung cancer. Methods Totally 76 cases of lung caneer diagnosed in our hospital during the past 2014 -2016 years were divided into two groups： the observation group of Shenqi pollen tab- lets combined with chemotherapy and the control group treated with chemotherapy. Follow up the patientg efficacy and prognostic information. This study analyzed and discussed the short- term prognosis of 3 months follow-up, and com- pared the discussion. Statistical analysis was performed using the SPSS16.0 statistical package. Results Complete re- mission rate of the observation group NSCLC was 3.33%, no patients with complete remission in tho control group; Compared with the control group, the observation group were stable and higher than the control group, the observation group in case the proportion was significantly lower than that of the control group, P 〈 0. 01 ; In addition to the two groups of the total effective rate comparison also suggested that the observation group than the control group P 〈0. 01. In the patients with small ceil lung cancer, the observation group and the control group were followed up for 3 months, and the curative effect was similar to that of the non small cell lung cancer patients. NSCLC analysis ahowed that the prognosis of the patients in the observation group to improve the quality of life of the proportion was 59. 09%, higher than 45.45 % in the control group, P 〈 0. 05 ; Lower the quality of life of the proportion was lower than that of the control group showed P 〈0. 01 ; Observation group of 3 months of follow- up, the recurrence rate was 4.55%, significantlylower than that of control group, P 〈0.01. in patients with small cell lung cancer, the quality of life improvement in theobservation group was higher than that in the control group, P 〈 0. 01, while the proportion of stability was lower than that of the control group, P 〈0. 05. The metastasis rate of the observation group in 3 months follow- up was 12.50%, which was significantly lower than that of the control group, P 〈 0.05. Conclusion Shenqi pollen tablet combined with chemotherapy has good effect on short - term prognosis of NSCLC and quality of life in patients with small cell lung canc- er, especially for patients with NSCLC is more obvious; In addition of Shenqi pollen tablet combined with chemotherapy can reduce the recurrence rate of patients with NSCLC and small cell lung cancer in a certain extent, the transfer rate.