LPS与LPT在早期卵巢癌全面分期手术中的治疗效果研究

Study on the effect of LPS and LPT in comprehensive surgical staging during the treatment of early stage ovarian cancer

目的探讨腹腔镜(LPS)与开腹手术(LPT)在早期卵巢癌全面分期手术中的应用价值。方法回顾性分析接受手术治疗的150例早期卵巢癌患者的临床资料,根据手术方式不同将患者分为LPS组和LPT组,每组各75例。观察两组患者的手术一般情况,并对两组患者的手术效果、术后恢复情况、肿瘤标志物水平和1年生存率进行比较。结果 LPS组患者的手术时间、术后住院时间均明显短于LPT组(P<0.001),术中出血量明显少于LPT组(P<0.001);LPS组患者的腹主动脉旁淋巴结切除数、盆腔淋巴结切除数均明显多于LPT组(P<0.001);LPS组患者术后胃肠功能恢复时间明显短于LPT组(P<0.001),但两组患者术后并发症发生率比较,差异无统计学意义(P>0.05);LPS组患者手术前后HE4、CA125水平差值均明显高于LPT组(P<0.001);两组患者的1年生存率比较,差异无统计学意义(P>0.05)。结论 LPS在早期卵巢癌全面分期手术中有较好的应用价值,可促进患者术后康复,具有良好的临床应用价值。

Objective To investigate the value of laparoscopic （LPS） and laparotomy （LPT） in the treatment of early-stage ovarian cancer. Method The clinical data of 150 patients with early-stage ovarian cancer were retrospectively ana-lyzed. Patients were grouped as LPS group and LPT group as per respective surgeries delivered, with 75 patients in each. The general conditions, surgery effect, postoperative recovery, tumor markers and 1-year survival rate of the two groups were observed and compared. Result The operative time and postoperative hospital stay of LPS group were shorter than those of LPT group （P〈0.001）, and so did the intraoperative blood loss （P〈0.001）;In the LPS group, there were more pa-ra-aortic lymph nodes and pelvic lymph nodes were resected than LPT group （P〈0.001）;LPS group had faster recovery of postoperative gastrointestinal function than the LPT group （P〈0.001）, while the incidence of postoperative complica-tions were similar in both groups （P〉0.05）; the difference of HE4 and CA125 levels before and after surgery in LPS group was greater than that in LPT group （P〈0.001）;and the 1-year survival rates were also comparable in the two groups （P〉0.05）. Conclusion LPS is effectively applicable in comprehensive surgical staging for early-stage ovarian cancer, it can promote postoperative recovery, and is clinically beneficial.