依替米星联合胸腺肽肠溶片方案治疗耐多药肺结核的疗效观察

Efficacy observation of etimicin combined with thymopeptide enteric-coated tablets regimen for the treatment of multidrug-resistant tuberculosis

目的探讨依替米星联合胸腺肽肠溶片方案治疗耐多药肺结核的疗效。方法 160例耐多药肺结核患者,采用随机数字法分为对照组和治疗组,每组80例。对照组采用常规抗痨方案治疗,治疗组在常规抗痨方案基础上采用依替米星联合胸腺肽肠溶片治疗,两组均完成12个月治疗,对比两组患者的病灶吸收总有效率、痰菌转阴率以及主要并发症发生率。结果治疗组患者病灶吸收总有效率为91.25%,显著优于对照组的72.50%(P<0.05)。治疗组患者在接受3、6、9、12个月治疗后,痰菌转阴率均明显高于对照组(P<0.05)。治疗组患者主要并发症发生率为5.00%,显著低于对照组的15.00%(P<0.05)。结论依替米星联合胸腺肽肠溶片方案治疗耐多药肺结核,病灶吸收总有效率高,痰菌转阴速度快,并发症发生率低,治疗肾功能正常的耐多药肺结核患者过程中,引起肾功能损害几率很低,停药后能很快恢复正常肾功能,治疗效果显著,值得推广应用。

Objective To investigate the efficacy of etimicin combined with thymopeptide enteric-coated tablets regimen for the treatment of multidrug-resistant tuberculosis. Methods A total of 160 muhidrug-resistant tuberculosis patients were divided by random number table method into control group and treatment group, with 80 cases in each group. The control group was treated with conventional anti-tuberculosis regimen, and the treatment group also received etimicin and thymopeptide enteric-coated tablets. Both groups completed 12 months of treatment, and comparison were made on total lesions absorption efficacy, sputum negative-conversion rate and incidence of major complications in two groups. Results The treatment group had obviously better total effective rate of lesions absorption as 91.25% than 72.50% in the control group （P〈0.05）. After 3, 6,9 and 12 months of treatment, the treatment group had higher sputum negative-conversion rate than the control group （P〈0.05）. The treatment group had obviously lower incidence of major complications as 5.00% than 15.00% in the control group （P〈0.05）. Conclusion Combination of etimicin and thymopeptide enteric-coated tablets shows remarkable treatment effect in treating multidrug-resistant tuberculosis, and it provides high total lesion~ absorption efficacy, rapid sputum transactasis, low incidence of complications. In the course of treatment of multidrug-resistant tuberculosis patients with normal renal function, the risk of renal function impairment is very low, and＇the normal renal function can be recovered soon after drug withdrawal. So it is worthy of popularization and＇application.