阿司匹林联合氯吡格雷治疗急性心肌梗死的临床疗效

Clinical efficacy of aspirin combined with clopidogrel in the treatment of acute myocardial infarction

目的研究急性心肌梗死患者使用阿司匹林和氯吡格雷联合治疗的治疗效果。方法 100例急性心肌梗死患者,随机分为对照组与观察组,每组50例。对照组患者服用阿司匹林,观察组患者在此基础上联合服用氯吡格雷。比较两组的治疗效果。结果观察组患者治疗后活化部分凝血活酶时间(APTT)为(37.28±7.37)s、凝血酶原时间(PT)为(11.25±2.14)s、纤维蛋白原(FIB)为(3.33±0.56)g/L,均明显优于对照组的(39.31±7.41)s、(13.47±2.46)s、(4.46±0.47)g/L,差异均具有统计学意义(P<0.05)。观察组患者的再闭塞率为4.00%、血管再通率为72.00%、左室射血分数(LVEF)为(46.45±7.03)%,均优于对照组的16.00%、52.00%、(34.22±7.56)%,差异均具有统计学意义(P<0.05)。结论阿司匹林和氯吡格雷联合使用治疗急性心肌梗死,可以十分有效的抑制血小板聚集,该治疗效果明显优于单独使用阿司匹林。

Objective To study the treatment effect of acute myocardial infarction patients treated with aspirin and clopidogrel. Methods A total of 100 aeute myocardial infarction patients were randomly divided into control group and observation group, with 50 cases in each group. The control group was treated with aspirin, and the observation group was also treated with clopidogrel. Treatment effect in two groups was compared. Results After treatment, the observation group had activated partial thromboplastin time （AP＇[T） as （37.28± 7.37） s, prothromhin time （PT） as （11.25 ± 2.14） s, fibrinogen （FIB） as （3.33 ± 0.56） g/L, which were obviously better than （39.31± 7.41） s, （13.47 ±2.46） s and （4.46 ±0.47） g/L in the control group. Their difference had statistical significance （P〈0.05）. The observation group had re-occlusion rate as 4.00%, vascular recanalization rate as 72.00%, left ventricular ejection fraction （LVEF） as （46.45 ± 7.03）%, which were all better than 16.00%, 52.00% and （34.22 ± 7.56）% in the control group, and their difference had statistical significance （P〈0.05）. Conclusion Combination of aspirin and clopidogrel in the treatment of acute myocardial infarction is effective in inhibiting platelet aggregation, and the therapeutic effect is obviously superior to aspirin alone.