天津地区健康体检人群2007-2015年血清尿酸水平变化趋势分析

Trend analysis of serum uric acid levels in health check-up subjects of Tianjin municipality 2007-2015

目的 了解天津地区健康体检人群的血清尿酸水平变化趋势.方法 对2007-2015年266 043例次体检者根据不同性别、不同年龄组,分析血清尿酸水平及高尿酸血症（HUA）检出率在9年间的变化趋势.结果 血清尿酸水平在2007-2015年呈上升趋势,男性（347 ±73） ～ （373 ±78）μmol/L,女性（253 ±59） ～ （267±61）μmol/L;男性HUA 2015年检出率20.9％ （4 589/21 953）,是2007年17.5％（1 434/8 195）的1.19倍,且9年间HUA总检出率趋势检验差异有统计学意义（x2=270.30,P=0.00）;女性9年间HUA检出率的趋势检验差异有统计学意义（x2=15.10,P=0.00）.各年度中男性HUA检出率均高于女性（P＜0.01）.年龄分组后,2009-2015年间男性HUA检出率随年龄增加而降低,青年组（20 ～ 39岁）检出率＞中年组（40～59岁）＞老年组（≥60岁）,7年间（2009-2015年）男性青年组和中年组的HUA检出率趋势检验差异有统计学意义（x2值为14.11 ～233.90,均P=0.00）;女性HUA检出率随年龄增加而增加,老年组患病率＞中年组＞青年组,9年间女性青年组HUA检出率趋势检验有统计学意义（x2值为115.30 ～ 480.20,均P=0.00）.多元线性回归分析显示,年龄对血尿酸水平影响较大,其次为性别和高脂血症.结论 天津市健康体检人群以男性青年组和女性老年组有较高的HUA检出率,青年和中年人群HUA检出率存在逐年升高趋势,应将20～59岁人群作为重点防治人群.

Objective To assess the changing trend of serum uric acid （SUA） levles in health check-up subjects of Tianjin municipality 2007-2015.Method Data were collected from 266 043 subjects receiving annual health check-up from 2007 to 2015 in Tianjin municipality.Changing trends of SUA levels and incidence of hyperuricemia were analyzed during the 9 year period.Results From 2007 to 2015 SUA levels in males were increased from （347 ± 73） μmol/L to （373± 78） μmol/L,while in females were increased from（253 ± 59） μmol/L to （267± 61） μmol/L.The trend test showed that both for men and woinen the incidence of hypemricemia was increased in each year （men：x2 =270.30,women：x2 =15.10,both P =0.00）.The incidence of hyperuricemia by each year was increased more markedly in men than that in women （x2 level：194.80-1 877.00,all P =0.00）.The incidence of hyperuricemia in young adults （20-39） was higher than that in middle-ages （40-59）,and the latter was higher than that in elderly （〉 60）.For the 7-year （2009-2015） incidence of hyperuricemia in young and middle-aged men,the trend test showed statistical siganificance （x2 level：14.11-233.90,all P =0.00）.By contrast,the incidence hyperuricemia in women was increased with aging,and for the 9-year incidence of hyperuricemia in young women,the trend test showed statistical siganificance （x2 level：115.30-480.20,all P =0.00）.Conclusion The incidence rates of hyperuricemia are high in Tianjin health check-up subjects,especiallly in young males and old females.There is a time trend of increasing incidence of hyperuricemia in the young and middle-aged subjects.The results indicate that the prevention and control of hyperuricemia in Tianjin are of clinical and social significance.