脓毒症的免疫机制研究进展

Immunologic mechanisms underlying sepsis

脓毒症是重症监护病房的第一位死亡原因.脓毒症的发病机制极其复杂,免疫功能紊乱在其发生、发展过程中具有重要作用.脓毒症的免疫紊乱包括免疫细胞凋亡、调节性T细胞增加等.文内介绍脓毒症免疫机制的研究进展.

Sepsis remains the leading cause of death in intensive care unit.The pathogenesis of sepsis is extremely complex.Immune dysfunction plays an important role in the occurrence and development of sepsis.Many mechanisms are responsible for sepsis induced immune-suppression,including apoptotic depletion of immune cells,increased T regulatory and myeloid-derived suppressor cells,and cellular exhaustion.The article provided a brief review on the advance of immunologic mechanisms underlying sepsis.