Kaposi肉瘤治疗的研究进展

Treatment of Kaposi＇s sarcoma

Kaposi肉瘤的治疗应依据不同临床类型，制定个体化方案。常用治疗方法有电化学疗法、放疗、物理治疗（如硝酸银、液氮冷冻、弹力长筒袜）和皮损内注射等，适用于经典型Kaposi肉瘤及其他类型Kaposi肉瘤的皮肤损害。常用治疗药物有足叶乙甙、紫杉醇、阿霉素、雷帕霉素、吉西他滨等，适用于各Kaposi肉瘤。Kaposi肉瘤的治疗尚缺乏标准化指南，以上治疗远期疗效欠佳。目前，新治疗靶标的研究主要集中在阻止成瘤过程、炎症调控、阻止病毒复制、细胞周期的调控等方面。

Treatment of Kaposi＇ s sarcoma should be individualized according to different clinical types. Common therapies include electrochemical therapy, radiotherapy, physical therapy （such as silver nitrate cauterization, liquid nitrogen cryotherapy and compression stockings） and intralesional injection, etc., which are suitable for skin lesions of classic and other types of Kaposi＇ s sarcoma. Commonly used drugs include etoposide, paclitaxel, doxorubicin, rapamycin, gemcitabine, etc., and they are suitable for all types of Kaposi＇s sarcoma. There are still no standard guidelines for the treatment of Kaposi＇s sarcoma, and the long-term efficacy of the above therapies is poor. At present, new therapeutic targets mainly focus on the prevention of tumor formation and virus replication, inflammation regulation and cell cycle control.