加味补阳还五汤联合常规西医疗法治疗急性脑梗死临床研究

Clinical Study of Modified Buyang Huanwu Tang Combined with Routine Western Medicine Therapy for Acute Cerebral Infarction

目的:观察加味补阳还五汤联合常规西医疗法治疗急性脑梗死的临床效果。方法:选取226例急性脑梗死气虚血瘀证患者,随机分为2组各113例,治疗组采用常规西医疗法结合加味补阳还五汤治疗,对照组以常规西医疗法治疗。2组患者均治疗2周。观察2组患者的临床症状改善情况,比较治疗前后2组患者的血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、超敏C-反应蛋白(hs-CRP)含量和美国国立卫生研究院卒中量表(NIHSS)评分。结果:治疗后,治疗组总有效率为93.8%,对照组总有效率为80.5%,2组比较,差异有统计学意义(P<0.01)。2组血清TNF-α、IL-6、hs-CRP和NIHSS评分均较治疗前有不同程度的下降(P<0.01,P<0.05),治疗组各项指标值均低于对照组(P<0.05)。结论:加味补阳还五汤联合常规西医疗法治疗急性脑梗死气虚血瘀证患者,可明显缓解临床症状、改善神经功能,降低炎症反应,提高治疗效果。

Objective： To observe the clinical effect of modified Buyang Huanwu tang combined with routine western medicine therapy for acute cerebral infarction. Methods： Selected 226 cases of patients with acute cerebral infarction with qi deficiency and blood stasis syndrome, and divided them into two groups randomly, 113 cases in each group. The treatment group was treated with routine western medicine therapy combined with Buyang Huanwu tang, while the control group was treated with routine western medicine therapy. Both groups received treatment for two weeks. Observed the improvements of clinical symptoms, and compared the content of serum tumor necrosis factor-α（TNF-α）, interleukin-6（IL-6）, high sensitive C-reactive protein（hs-CRP） and score of National institute of health stroke scale（NIHSS） in both groups before and after treatment. Results： After treatment, the total effective rate was 93.8% in the treatment group and 80.5% in the control group,the difference being significant（P〈0.01）. Serum TNF-α, IL-6, hs-CRP and NIHSS scores in both groups were decreased to different degree, comparing with those before treatment（P〈0.01, P〈0.05）. All indexes in the treatment group were lower than those in the control group（P〈0.05）. Conclusion： The therapy of modified Buyang Huanwu tang combined with routine western medicine therapy for acute cerebral infarction can effectively relieve clinical symptoms, improve neurological function,reduce inflammatory reaction, and enhance the curative effect.