清热利湿活血汤联合门冬氨酸钾镁注射液治疗急性黄疸型肝炎临床观察

Clinical Observation of Qingre Lishi Huoxue Tang Combined with Potassium Magnesium Aspartate Injection for Acute Icteric Hepatitis

目的:观察清热利湿活血汤联合门冬氨酸钾镁注射液治疗急性黄疸型肝炎的临床效果。方法:研究病例来源于本院收治的80例湿热蕴结夹瘀型急性黄疸型肝炎患者,按照治疗方法的不同分为研究组和对照组各40例,研究组给予清热利湿活血汤联合门冬氨酸钾镁注射液治疗,对照组仅给予门冬氨酸钾镁注射液治疗,比较2组的临床疗效、退黄时间及肝功能改善情况。结果:治疗后,研究组总有效率为90.0%,对照组总有效率为67.5%,2组比较,差异有统计学意义(P<0.05)。2组总胆红素(TBil)、谷丙转氨酶(ALT)、谷草转氨酶(AST)均较治疗前降低(P<0.05),研究组3项指标值均低于对照组(P<0.05)。2组身目俱黄、胁腹胀痛、发热、口干口苦、恶心及身痒评分均较治疗前降低(P<0.05),研究组6项评分均低于对照组(P<0.05)。研究组平均退黄时间短于对照组(P<0.05)。结论:采用清热利湿活血汤联合门冬氨酸钾镁注射液治疗急性黄疸型肝炎可有效改善患者的肝功能及临床症状,促使黄疸消退,临床疗效显著。

Objective： To observe the clinical effect of Qingre Lishi Huoxue Tang combined with potassium magnesium aspartate injection for acute icteric hepatitis. Methods： Eighty cases of patients with acute icteric hepatitis of damp-heat accumulation and blood stasis symdrome were selected from the infectious department of the hospital. According to different therapies, they were divided into the study group and the control group randomly, 40 cases in each group. The study group was treated with Qingre Lishi Huoxue Tang combined with potassium magnesium aspartate injection, while the control group was only treated with potassium magnesium aspartate injection. Compared the clinical symptom, time of clearing jaundice and improvement of liver function in both groups. Results： After treatment, the total effective rate was 90.0% in the study group and 67.5% in the control group, the difference being significant（P〈0.05）. The levels of total bilirubin（TBil）, alanine aminotransferase（ALT） and aspartate aminotransferase（AST） in both groups were decreased when compared with those before treatment（P〈0.05）, and the three indexes in the study group were lower than those in the control group（P〈0.05）. Scores of yellow skin and eyes, abdominal distension and pain, fever, dry and bitter mouth, nausea, and itching were reduced when compared with those before treatment（P〈0.05）, and the six scores in the study group were lower than those in the control group（P〈0.05）. The average time of clearing jaundice in the study group was shorter than that in the control group（P〈0.05）.Conclusion： The therapy of Qingre Lishi Huoxue Tang combined with potassium magnesium aspartate injection for acute icteric hepatitis can effectively improve liver function as well as clinical symptoms and promote the clearance of jaundice, which has remarkable curative effect.