复方夏天无片治疗腰椎间盘突出症后期下肢麻木疗效观察

Curative Effect Observation of Applying Compound Rhizoma Corydalis Decumbentis Tablets in Treating Lower Limb Numbness That Appeared in Late Stage of LIDH

目的:观察口服复方夏天无片治疗腰椎间盘突出症后期下肢麻木的临床疗效。方法:将腰椎间盘突出症100例患者随机分为2组各50例。对照组同时口服复方夏天无片和弥可保片;治疗组第1月每次加服复方夏天无片1片,余同对照组;2组疗程均为3月。观察2组临床疗效,腰椎功能,治疗1月、3月后麻木缓解情况以及不良反应发生情况。结果:治疗3月后,总有效率观察组94.0%,对照组80.0%,2组比较,差异有统计学意义(P<0.05)。治疗1月后、治疗3月后,2组麻木视觉模拟评分法(VAS)评分分别与治疗前比较,均有降低,差异均有统计学意义(P<0.01,P<0.05),2组间比较,差异有统计学意义(P<0.01,P<0.05),治疗组优于对照组。治疗3月后,治疗组腰椎日本骨科学会(JOA)评分比对照组高,差异有统计学意义(P<0.05)。2组均未出现严重不良反应。不良反应发生率治疗组8.0%,对照组6.0%,2组比较,差异无统计学意义(P>0.05)。结论:口服复方夏天无可有效缓解小腿麻木症状,短期适当提高其用量可取得更好的疗效,且并不增加不良反应。

Objective： To observe the clinical curative effect of applying compound rhizoma corydalis decumbentis tablets in treating lower limb numbness that appeared in late stage of lumbar intervertebral disc herniation（LIDH）. Methods： Selected 100 LIDH patients and divided them into two groups, 50 cases in each group. The control group was given oral administration of compound rhizoma corydalis decumbentis tablets and Mecobalamin tablets at the same time, while the treatment group was given the same treatment except giving an additional compound rhizoma corydalis decumbentis tablet every time during the first month of treatment. Treatment for both groups lasted for three months. Observed clinical effect, lumbar function, relief of numbness after treatment for one month and three months, and incidence of adverse reaction in both groups. Results： After three months of treatment, the total effective rate was 94.0% in the treatment group, and was 80.0% in the control group,the difference being significant（P〈0.05）. After one month and three months of treatment, Visual analogue Scale（VAS） in both groups was lower than that before treatment, differences being significant（P〈0.01, P〈0.05）, and the score of the treatment group was better than that of the control group, the difference being significant（P〈0.01, P〈0.05）. After three months of treatment, Japanese orthopaedic association（JOA） score of the treatment group was higher than that of the control group, the difference being significant（P〈0.05）. There was no adverse reaction in both groups. The adverse reaction rate was 8.0% in the treatment group, and was 6.0% in the control group, the difference being not significant（P〈0.05）. Conclusion： Oral administration of compound rhizoma corydalis decumbentis tablets can relieve numbness of lower limb, which may has better efficacy with no additional adverse reaction if increases dosage in the short term properly.