儿童回春颗粒联合喜炎平雾化吸入治疗小儿上呼吸道感染临床观察

Clinical Observation of Children Huichun Granules Combined with Aerosol Inhalation of Xiyanping for Children with Upper Respiratory Tract Infection

目的:观察儿童回春颗粒联合喜炎平雾化吸入治疗小儿上呼吸道感染的临床疗效,及对患儿血清炎症因子和免疫功能的影响。方法:将本院214例上呼吸道感染患儿随机分为对照组和观察组,每组107例。对照组给予喜炎平雾化吸入,观察组在此基础上加用儿童回春颗粒口服。观察2组治疗前后炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]、T细胞亚群(CD4、CD8、CD4/CD8)的变化,比较2组症状(发热、咳嗽、流涕)改善时间,评估治疗效果。结果:治疗后,2组TNF-α、IL-6水平均较治疗前降低(P<0.05);观察组的TNF-α、IL-6水平均低于对照组(P<0.05)。治疗后,2组CD4水平及CD4/CD8均较治疗前上升(P<0.05),CD8水平均较治疗前下降(P<0.05);观察组的CD4水平及CD4/CD8均高于对照组(P<0.05),CD8水平低于对照组(P<0.05)。观察组发热、咳嗽及流涕消失时间均短于对照组(P<0.01)。观察组治疗总有效率92.5%,高于对照组的80.4%(P<0.05)。结论:儿童回春颗粒联合喜炎平雾化吸入可有效控制上呼吸道感染患儿的炎症反应,改善免疫功能,治疗效果满意。

Objective： To observe the clinical effect of children Huichun granules combined with aerosol inhalation of Xiyanping for children with upper respiratory tract infection and its effect on inflammatory factors and immune function of the children. Methods： Divided 214 cases of children with upper respiratory tract infection in our hospital into the control group and the observation group randomly, 107 cases in each group. Both groups received aerosol inhalation of Xiyanping, while the observation group additionally received Huichun granules orally. Observed changes of levels of inflammatory factors [tumor necrosis factor-α（TNF-α） and interleukin-6（IL-6）] and T cell subsets（CD4, CD8 and CD4/CD8） in both groups before and after treatment. Compared the improvement time of symptoms（fever, cough and nasal discharge） in both groups, and evaluated the curative effect. Results： After treatment, levels of TNF-α and IL-6 in both groups were decreased when compared with those before treatment（P〈0.05）; levels of TNF-α and IL-6 in the observation group were both lower than those in the control group（P〈0.05）. After treatment, comparing with those before treatment, levels of CD4 and CD4/CD8 in both groups were increased（P〈0.05）, while CD8 levels in both groups were declined（P〈0.05）; levels of CD4 and CD4/CD8 in the observation group were both higher than those in the control group（P〈0.05）, while CD8 levels in the observation group were lower than those in the control group（P〈0.05）. The disappearance time of fever, cough and nasal discharge in the observation group was all shorter than that in the control group（P〈0.05）. The total effective rate was 92.5% in the observation group, being higher than 80.4% in the control group（P〈0.05）. Conclusion： The therapy of children Huichun granules combined with aerosol inhalation of Xiyanping can effectively control the inflammatory reaction of children with upper respiratory tract infection and improve the immune function of children with satisfactory curative effect.