附子逍遥散配合针刺治疗抑郁症肝气郁结证临床观察

Clinical Observation of Fuzi Xiaoyao San Combined with Acupuncture in Treating MDD patients with Syndrome of Liver-Qi Stagnation

目的:观察附子逍遥散配合针刺治疗抑郁症(MDD)肝气郁结证的临床疗效。方法:选取在本院治疗的96例MDD肝气郁结证患者,按照入院顺序分为观察组与对照组各48例。观察组给予附子逍遥散合针刺治疗,对照组给予西药治疗。观察2组治疗前后汉密尔顿抑郁量表(HAMD)评分、血清5-羟色胺(5-HT)含量的变化,评估患者的治疗效果及统计不良反应。结果:治疗2周、4周、6周后,2组HAMD评分均较治疗前降低(P<0.05),观察组的HAMD评分较对照组下降更显著(P<0.05)。治疗后,2组5-HT含量均较治疗前升高(P<0.01),观察组的血清5-HT含量较对照组升高更明显(P<0.01)。观察组治疗总有效率89.58%,对照组治疗总有效率66.67%,2组比较,差异有统计学意义(P<0.01)。观察组不良反应发生率8.33%,对照组不良反应发生率27.08%,2组比较,差异有统计学意义(P<0.05)。结论:附子逍遥散配合针刺治疗MDD肝气郁结证,疗效优于西药治疗,可有效减轻患者的抑郁程度,提高血清5-HT含量,不良反应少。

Objective： To observe the clinical effect of Fuzi Xiaoyao san combined with acupuncture in treating major depressive disorder（MDD） with syndrome of liver-qi stagnation. Methods： Selected 96 cases of patients with syndrome of liver-qi stagnation in our hospital, and divided them into the observation group and the control group according to their order of hospitalization, 48 cases in each group. The observation group was given therapy of Fuzi Xiaoyao san combined with acupuncture, while the control group was given therapy of western medicine. Observed change of Hamilton depressive scale（HAMD） score and content of serum 5-hydroxytryptamine（5-HT） of the two groups before and after treatment, evaluated curative effect of patients and recorded incidence of adverse reaction. Results： After two weeks, four weeks and six weeks of treatment, HAMD scores of the two groups were lower than those before treatment（P〈0.05）, and the decrease in the observation group was more significant（P〈0.05）. After treatment, 5-HT content of the two groups were higher than that before treatment, and the increase in the observation group was more significant（P〈0.01）. The total clinical effective rate was 89.58% in the observation group and 66.67% in the control group, the difference being significant（P〈0.05）. The incidence of adverse reaction was 8.33% in the observation group and 27.08% in the control group, the difference being significant（P〈0.05）.Conclusion： Fuzi Xiaoyao san combined with acupuncture has better efficacy than western medicine in treating MDD with syndrome of liver-qi stagnation, which can relive depression, improve content of serum 5-HT, and has less adverse reaction.