烟曲霉素类药物在农业领域的应用研究进展

Research Progress on Application of Fumagillin in Agriculture Field

烟曲霉素是一种从烟曲霉菌(Aspergillus fumigatus)提取液中分离出来的霉菌毒素,其在防治微孢子虫病方面有显著疗效,在农业中广泛作为抗生素类药物用于治疗此病。综述了烟曲霉素的起源、分子结构和化学性质,烟曲霉素类药物在国内外的研究现状,以及烟曲霉素类药物在蜜蜂、鱼类等农业领域的应用;并对合成低毒的烟曲霉素类药物、合成烟曲霉素类似物或代谢物的相关研究及其在农业中的应用前景进行了展望;旨在为烟曲霉素相关药物在我国农业领域的应用提供一些帮助,以及为今后合成一种低毒、高效的烟曲霉素药物提供理论依据。

Fumagillin is a kind of mycotoxin isolated from Aspergillus fumigates.It is widely used in agriculture as antibiotic curing microsporidiosis due to its significant effectiveness.This paper summarized the recent research progress made at home and abroad on fumagillin,including its origin,molecular structure and chemical property;and fumagillin application in honey bee,fishery,etc.agriculture fields.The paper also reviewed the research situation and direction concerning synthesizing of low toxicity fumagillin drugs and synthesizing fumagillin analogs or metabolites,and prospected its application in agriculture,aiming at providing assistance for fumagillin related drugs application in Chinese agriculture,and theoretical basis for synthesis of low toxicity,high efficiency fumagillin drugs in the future.