急性肾损伤对远处脏器损伤的影响

The effect of acute kidney injury on other organs

急性肾损伤(acute kidney injury,AKI)是危重患者常见并发症,也是患者预后不良的独立危险因素。目前尚无治疗AKI的特异性药物。此外,虽然透析技术日益进步,透析依赖性的AKI仍具有高死亡率。因此,仅仅关注AKI患者肾脏损伤,对改善其预后是不够的。最新基础和临床研究阐述了AKI患者肾脏和远处脏器之间复杂的相互作用。本综述旨在简述AKI中肾脏与远处脏器间(心脏、肺脏、肝脏)交互作用的新进展及潜在治疗靶点,为临床治疗和预防AKI后多脏器功能衰竭提供新思路。

Acute kidney injury （AKI） is the most common complication in critically ill patients, and is also an independent risk factor for unfavorable outcomes. There are no specific drugs for AKI at the present time. The mortality rate is higher in dialysis dependent AKI patients. It is insufficient to improve the outcome of AKI patients by merely focusing on kidney injury and renal dysfunction. Recent basic and clinical researches show that there is a complex cross-talk between kidney and other organs. This review aims to give a brief introduction about the recent progress and potential therapeutic targets in organ cross-talk between kidney and other organs （heart, lung and liver） in AKI, in order to provide new ideas for clinical treatment and prevention of multiple organ failure after AKI.