c-Src在上皮性卵巢癌组织中的表达及意义

Expression and Clinical Significance of c-Src in the Epithelial Ovarian Carcinoma

目的:探讨上皮性卵巢癌组织中细胞肉瘤蛋白(Cell sarcoma,c-Src)的表达及其其临床意义。方法:通过Western blotting方法检测4例正常卵巢组织及21例上皮性卵巢组织中c-Src蛋白的表达。同时,通过免疫组化的方法检测26例正常卵巢组织和134例上皮性卵巢癌组织中c-Src的表达。统计分析c-Src的表达与上皮性卵巢肿瘤的临床病理因素之间的关系。结果:与正常卵巢组织相比,上皮性卵巢癌组织中c-Src蛋白的表达明显增高。c-Src蛋白的过表达与上皮性卵巢癌患者的临床病理分期、组织学分化程度、淋巴结转移情况及肿瘤复发之间差异存在统计学意义(P<0.05),但与患者的年龄等因素均无显著相关性(P>0.05)。此外,c-Src蛋白的高表达,与上皮性卵巢癌患者的预后密切相关(P<0.05)。结论:c-Src在上皮性卵巢癌组织中过表达,且与肿瘤的恶性生物学行为密切相关,可能作为评估上皮性卵巢癌恶性程度、病情进展的重要指标及分子靶向疗法的新靶点。

Objective： we aim to determine the relationship between Cell sarcoma （c-Src） expression in patients with EOC and the disease phenotype. Methods： c-Src expression was evaluated using Western blotting analysis in 21 ovarian carcinomas and 4 normal ovarian tissues. Immunohistochemistry was used to evaluate c-Src expression in 134 ovarian carcinomas and 26 normal ovarian tissues. The association between c-Src expression and clinically pathologic characteristics wore also assessed in these patients. Results： Our results indicated elevated c-Src protein in EOCs compared with that in normal tissues. The overexpression of c-Src was significantly associated with aggressive features, such as advanced disease stage, poor histological grade, lymph node metastasis, and tumor recurrence （P〈0.05）. In addition, the overexpression of c-Sre is significantly associated with EOCs＇ prognosis. Conclusion： c-Src overexpression was significantly associated with the malignant biological behavior of tumor, suggesting c-Src as a potential preventive target in these patients.