稳心颗粒联合普罗帕酮用于心律失常的疗效研究及对血清hs-CRP、TNF-α、IL-6与心功能的影响

Curative Efficacy of Wenxin Granule Combined with Propafenone in Treatment of Arrhythmia and Serum Levels of hs-CRP, TNF-αand IL-6 and Heart Function

目的:探讨稳心颗粒联合普罗帕酮治疗心律失常的临床疗效研究及对血清高敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF)-α、白介素(IL)-6水平与心功能的影响。方法:选择2014年7月至2016年10月我院接诊的96例心律失常患者,通过随机数表法分为观察组(n=48)和对照组(n=48)。对照组给予普罗帕酮治疗,观察组在此基础上,联用稳心颗粒。治疗4周后,比较两组血清hs-CRP、TNF-α、IL-6水平、心功能、临床疗效以及不良反应的发生情况。结果:治疗后,观察组临床疗效总有效率明显高于对照组(P<0.05);血清hs-CRP、TNF-α、IL-6水平均明显低于对照组(P<0.05);观察组左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)显著低于对照组,左室射血分数(LVEF)明显高于对照组(P<0.05);观察组不良反应发生率明显低于对照组(P<0.05)。结论:稳心颗粒联合普罗帕酮治疗心律失常的效果显著,可有效改善患者心功能,安全性高,可能与其降低血清hs-CRP、TNF-α、IL-6表达有关。

Objective： To study the curative efficacy ofwenxin granule combined with propafenone in the treatment of arrhythmia and its effects on the serum levels ofhs-CRP, TNF-α, IL-6 and heart function. Methods： 96 patients of arrhythmia who were treated from July 2014 to October 2016 in our hospital were selected and randomly divided into the observation group （n=48） and the control group （n=48）. The control group was treated with propafenone, while the observation group was treated with wenxin granuleon. Then the serum levels of hs-CRP, TNF-α and IL-6, heart function, clinical efficacy and incidence of adverse reactions were observed and compared between the two groups before and after the treatment. Results： After treatment, the total effective rate of observation group was significantly higher than that of the control group （P〈0.05）. The serum levels of hs-CRP, TNF-α and IL-6 Of observation group were significantly lower than those of the control group （P〈0.05）; the left ventricular end diastolic dimension （LVEDD） and left ventricular end systolic diameter （LVESD） of observation group were significantly lower than those of the control group, and the left ventricular ejection fraction （LVEF） was significantly higher than that of control group（P〈0.05）; the incidence of adverse reactions in the observation group was significantly lower than that of the control group （P〈0.05）. Conelusion： Wenxin granule combined with propafenone was effective for arrhythmia, it could effectively improve the heart fimction and high safety, which might be related to the decrease of serum hs-CRP, TNF- and IL-6 levels.