摘要
Calponin(类肌钙蛋白)是一个肌动蛋白细肌丝相关的调节蛋白,表达在平滑肌细胞和许多类型的非肌细胞中。哺乳动物有Calponin 1、Calponin 2和Calponin 3三个亚型,分别由三个同源基因CNN1、CNN2和CNN3编码,表达于不同的细胞类型,并执行细胞类型特异性的生理功能。除了调节平滑肌收缩功能,Calponin还调节非肌细胞肌动蛋白骨架的功能并参与多种细胞生命活动,如增殖、粘附、迁移、分化、吞噬和细胞融合等。本综述重点讨论Calponin亚型的基因进化、组织和细胞类型特异性表达、结构和功能的关系以及相关的调节机制。
Calponin is an actin filament-associated regulatory protein expressed in smooth muscle and many types of nonmuscle cells. Three calponin isoforms 1, 2, and 3 are encoded by three homologous genes CNN1, CNN2 and CNN3 in vertebrate species with cell type-specific expression and functions. Besides modulating the activity of smooth muscle myofilaments and contractility, calponin also regulates the functions of actin cytoskeleton in non-muscle cells during cell proliferation, adhesion, migration, differentiation, phagocytosis and fusion. This review focuses on the evolution, tissue and cell type-specific expression, structure-function relationships, transcriptional regulation and relevant mechanisms.
出处
《现代生物医学进展》
CAS
2017年第26期5185-5188,共4页
Progress in Modern Biomedicine
