双氯芬酸钠注射液对仔猪腹腔注射内毒素(LPS)的临床解热药效试验

Diclofenac Sodium Injection on Piglet Intraperitoneal Injection of Endotoxin(LPS) Clinical Efficacy of Antipyretic Test

双氯芬酸钠注射液在人药领域应用广泛,在临床上有很好的解热、镇痛效果。本试验目的是验证双氯芬酸钠注射液在靶动物猪上的解热效果。结果表明:(1)双氯芬酸钠注射液低剂量组在治疗猪发热方面具有一定的临床效果,但其效果稍差于对乙酰氨基酚组;(2)双氯芬酸钠注射液中、高剂量组的临床解热综合效果优于对乙酰氨基酚组;(3)从临床使用及经济角度考虑,选用中剂量作为解热的推荐剂量,即双氯芬酸钠临床肌肉注射给药剂量为0.05 m L/kg体重。

Diclofenac Sodium Injection is widely used in medicine, and has good antipyretic analgesic effect in clinic. The pur- pose of this study was to verify the effect of antipyretie in the target animal pigs on Diclofenac Sodium Injection. The results showed that： 1. Dielofenac Sodium Injection low dose group had a clinical effect in the treatment of swine fever, but the effect was slightly worse than the acetaminophen group; 2. Diclofenac Sodium Injection in the high dose group of comprehensive clinical effect of anti- pyretie was better than that of the aeetaminophen group ; 3. Considering the clinical use and from the economic point of view, the se- lection of the recommended dose as antipyretic, namely dielofenae sodium clinical dosage for intramuscular injection was 0.05 ml/kg body weight.