金匮泽泻汤颗粒治疗心下支饮型良性阵发性位置性眩晕的临床研究

Clinical Efficacy of Jinkui Zexie Decoction Particles in Treating Benign Paroxysmal Positional Vertigo( BPPV) with Xinxia Zhiyin Particles

目的:观察《金匮要略》经方泽泻汤颗粒(以下简称"金匮泽泻汤颗粒")治疗良性阵发性位置性眩晕(BPPV)的临床疗效和安全性。方法:选择中国中医科学院广安门医院、河南省中医院、北京博爱医院门诊就诊的BPPV患者212例,按随机数字表法分为治疗组(92例)和对照组(120例)。对照组给予改良Epley复位法,治疗组在对照组基础上给予金匮泽泻汤颗粒辨证加减,在治疗后第2天、2周、3个月进行眩晕残障程度、临床疗效、不良事件的评定。结果:治疗组在治疗后2 d、2周、3个月的DHI评分较同期对照组评分改善明显,治疗组在治疗后2 d、2周、3个月总有效率(76.09%、88.04%、95.65%)均优于对照组(61.67%、73.33%、83.33%)。治疗组病例变位试验、单侧水平半规管功能参数治疗后2 d、2周、3个月的阳性率低于对照组,随访3个月与治疗后2 d比较差异有统计学意义,组间不良反应发生情况差异无统计学意义。结论:金匮泽泻汤颗粒能改善心下支饮型良性阵发性位置性眩晕耳石复位后的临床疗效,减轻眩晕的残障程度及前庭功能,具有一定的远期疗效,临床安全性较好。

To observe the synopsis by Jinkui Zexie Decoction particles treat BPP（ BPPV） clinical curative effect.Methods： China academy of traditional Chinese medicine,Chinese medicine hospital in Henan province,Beijing fraternity hospital in outpatient clinic diagnosis standard of BPPV,212 cases of patients,according to the selected order were randomly divided into treatment group（ 92 cases） and control group（ 120 cases）. Treatment with an improved Epley reset method,the control group in the control group on the basis of given alisma golden soup particles dialectical add and subtract,the second day after treatment,2 weeks,3 months for vertigo degree of disability evaluation,clinical efficacy,adverse events. Results： the treatment group after treatment for 2 days,2 weeks,3 months of DHI score than control group score improved significantly during this period,the treatment group after treatment for 2 days,2 weeks,3 months of total effective rate（ 76. 09%, 88. 04%, 95. 65%） were better than control group（ 61. 67%, 73. 33%, 83. 33%）.Deformation test of treatment group cases,unilateral horizontal semicircular canal function of two parameters of 2 days after treatment,2 weeks,3 months of positive rate is lower than the control group; Followed up for 3 months and 2 days after treatment was statistically difference. Conclusion： Jinkui Zexie Decoction particles can improve BPPV after the clinical curative effect,reduce the disability rate of the dizziness and vestibular function,with good security.