中国人群TNF-α基因G308A多态性与冠状动脉粥样硬化性心脏病关系的Meta分析

Association between TNF-α-308G/A gene polymorphism and susceptibility to coronary atherosclerotic heart disease in Chinese population:a meta-analysis

目的研究TNF-α基因-308G/A多态性与中国人群冠状动脉粥样硬化性心脏病(coronary atherosclerotic heart disease,CHD)的关系。方法计算机检索Pub Med、Web of Science、CNKI、Wan Fang Data和VIP数据库,搜集TNF-α基因-308G/A多态性与中国人群CHD相关的病例-对照研究,检索时限均为建库至2017年2月。由两名研究者独立地进行文献筛选、资料提取和评价纳入研究的偏倚风险评价后,采用Stata 12.0软件进行Meta分析。结果最终纳入10个病例-对照研究,包括4 628例患者和4 362例对照人群。Meta分析结果显示:TNF-α基因-308G/A多态性与中国人群CHD易感性之间存在相关性[A vs.G:OR=1.13,95%CI(1.02,1.26),P=0.020;AA vs.GA/GG:OR=1.47,95%CI(1.02,2.12),P=0.038;AA vs.GG:OR=1.50,95%CI(1.04,2.16),P=0.029]。结论 TNF-α基因-308G/A多态性与中国人群CHD易感性之间存在相关性,A等位基因为其潜在危险因素。受纳入研究的数量与质量限制,上述结论尚需开展更多高质量研究予以验证。

Objective To investigate the association between TNF-α gene -308G/A polymorphism and the risk of coronary atherosclerotic heart disease （CHD） in Chinese population. Methods We searched PubMed, Web of Science, CNKI, WanFang Data and VIP Databases from inception to February 2017, to collect case-control studies about the association between TNF-α gene -308G/A polymorphism and risk of CHD in Chinese population. Two reviewers independently screened literature, extracted data and assessed the risk of bias of the included studies. Meta-analysis was performed by Stata 12.0 software. Results A total of 10 case-control studies were included. The results ofmeta-analysis showed a significant association between the TNF-α gene -308G/A polymorphism and CHD risk in Chinese population （A vs. G： OR=1.13, 95%CI 1.02 to 1.26, P=0.020; AA vs. GA/GG： OR=1.47, 95%CI 1.02 to 2.12, P=0.038; AA vs. GG： OR=1.50, 95%CI 1.04 to 2.16, P=0.029）. Conclusion The current evidence shows that the TNF-α gene -308G/A polymorphism may be associated with CHD risk in Chinese population and A allele may be a risk factor. Due to the limited quantity and quality of included studies, more high quality studies are needed to verify the above conclusion.