舒芬太尼复合右美托咪定在髋关节置换术后镇痛中的应用

Application of sufentanil combined with dexmedetomidine in hip arthroplasty analgesia

目的:探讨舒芬太尼复合右美托咪定在髋关节置换术后镇痛中的应用效果。方法:选取收治的行髋关节置换术患者40例作为研究对象,按照随机数字表法将其分成2组,每组20例。观察组给予舒芬太尼复合右美托咪定镇痛,对照组给予舒芬太尼镇痛,比较2组患者术后4 h(T_1),8 h(T_2),12 h(T_3),24 h(T_4),48 h(T_5)的视觉模拟疼痛(VAS)评分,Ramsay镇静评分及不良反应的发生情况。结果:观察组术后T_1,T_2,T_3,T_4,T_5的VAS评分较对照组均明显降低(P<0.01);观察组术后T_1,T_2,T_3,T_4,T_5的Ramsay镇静评分较对照组明显升高(P<0.01);2组不良反应发生率差异无统计学意义(P>0.05)。结论:舒芬太尼复合右美托咪定在髋关节置换术后镇痛中效果显著,值得临床推广应用。

Objective： To explore the application effect of sufentanil combined with dexmedetomidine in hip arthroplasty analgesia.Methods： 40 cases of hip replacement patients treated in our hospital from April 2015 to June 2016 were selected and divided into two groups,20 cases in each.The observation group was given sufentanil combined with dexmedetomidine analgesia,and the control group was given sufentanil analgesia only.Then the visual analogue scale （VAS） pain score,Ramsay sedation score and adverse reaction were compared between the two groups at 4h （T_1）,8h （T_2）,12h （T_3）,24h （T_4） and 48h （T_5） after the operation.Results： The VAS scores of the observation group were significantly lower than those of the control group at T_1,T_2,T_3,T_4 and T_5 after the operation （P 0.01）; the Ramsay sedation scores in the observation group were significantly higher than those in the control group at T_1,T_2,T_3,T_4 and T_5 （P 0.01）; there was no significant difference in the incidence of adverse reactions between the two groups （P 0.05）.Conclusion： The efficacy of dexmedetomidine combined with sufentanil in the application of postoperative analgesia after the hip replacement is significant,which is worthy of clinical application.