肠道菌群变化对中暑肠黏膜屏障的影响

Effect of gut microbiota changes on the intestinal mucosal barrier function in heatstroke

中暑使肠黏膜屏障功能受损,导致细菌及内毒素血症并引起续贯性器官损伤。因此,保护肠道屏障功能可作为防治中暑的中心环节。肠道菌群对肠道机械屏障、微生物屏障和免疫屏障都有重要影响,菌群变化造成肠道屏障破坏,肠源性细菌和内毒素进入循环增加,产生炎症因子,成为中暑发生的重要诱因,也是中暑病程进展的重要因素。补充益生菌可以改善屏障功能,减轻内毒素血症及炎症因子水平。因此,从肠道菌群影响的相关环节寻找"靶点",发现与中暑相关性高的益生菌,针对性地进行补充和干预,以对抗肠黏膜屏障破坏,可能成为将来中暑治疗和预防的有效策略。

Heatstroke impairs the intestinal mucosal barrier function, leading to bacteremia, endotoxemia and multiple organ dysfunction. Therefore, protecting intestinal barrier function is critical in the prevention and treatment of heatstroke. Gut microbiota has an important impact on intestinal mechanical, biological and immune barrier. Intestinal dysbacteriosis damages intestinal barrier, which leads to enterogenous bacteria and endotoxin from the intestinal lumen entering into the circulation and thus causes systemic inflammatory response syndrome. This process can trigger heatstroke and promote its development and progression. However, probiotics can reduce endotoximia and inflammatory cytokines by improving the intestinal barrier function. Therefore, according to the effect of gut microbiota on the relevant aspects of intestinal mucosal barrier, searching for target probiotics and intervention may be an effective strategy for the prevention and treatment of heatstroke against intestinal barrier damage.