磁共振定量技术在腹部实质性脏器铁过载中的研究进展

The research progress of magnetic resonance quantitative technique in the iron overload of the abdominal parenchyma organ

目的总结磁共振定量技术在腹部实质性脏器铁过载中的研究进展。方法通过复习国内外相关文献,总结磁共振定量技术和其他检查在铁过载研究中的现状及进展。结果 MRI多种序列检查技术已经改变了多种器官铁过载的研究模式,其在腹部实质性脏器铁过载的影像学诊断中有重要的临床意义。目前用于检测铁过载的MRI方法主要有:信号强度测量法[包括信号强度比(signal intensity ratio,SIR)和同反相位信号强度差异]、T2/R2测量法(如多回波mapping技术和Ferri Scan技术)、T2~*/R2~*测量法、Dixon及其衍生技术、超短回波时间(UTE)成像技术及磁敏感加权成像(包括常规磁敏感加权成像和定量磁敏感成像)。结论磁共振定量技术有望成为肝铁过载的首选检查方法,并有助于提高铁过载致胰腺损伤的早期检出率。

Objective To summarize the research progress of magnetic resonance quantitative technique in the iron overload of the abdominal parenchyma organ. Methods By reviewing the related literatures domesticly and abroad, the present status and progress of abdominal magnetic resonance quantitative technique and other examinations in the study of iron overload were analyzed. Results MRI multi-sequence examination technique had changed the research model of iron overload in different organs, and had important clinical significance in imaging diagnosis of abdominal parenchyma organ damage, so far, many techniques of MRI had been used in detection of iron overload, which included signal intensity measurements（including signal intensity ratio and signal intensity difference of positive and negative phases）, T2/R2 measurements, T2＊/R2＊ measurements, Dixon and its derivatization, ultrashort echo time technique and susceptibility weighted imaging （including conventional susceptibility weighted imaging and quantitative magnetic sensitive imaging）. Conclusion Magnetic resonance quantitative examination technique is expected to be the first choice for detection of hepatic iron overload, and can improve the early detection rate of iron overload pancreatic damage.