整合素与胃癌侵袭转移及预后关系的研究进展

Research progression of relationship between integrin and invasion, metastasis, or prognosis of gastric cancer

目的研究整合素与胃癌发生、发展、治疗及预后的关系。方法回顾近几年来有关整合素与胃癌相关研究的文献并加以分析。结果与胃癌关系较为密切的整合素主要有β1亚系整合素与αν亚系整合素,β1亚系整合素与胃癌的侵袭、转移等一系列生物学行为密切相关;αν亚系整合素与胃癌的病理分型、分级及分期有关,且αν亚系整合素成员ανβ3、ανβ5和ανβ6与胃癌的预后有关,其中的ανβ6可作为一个判断胃癌预后的有效独立指标。结论整合素家族成员与胃癌发生、发展、治疗及预后关系密切,但其所涉及的机制如信号转导通路尚不完全清楚,相信随着对整合素研究的不断深入,人们将逐渐阐明其中的分子机制,为胃癌的诊疗和预后判断提供新的思路和方法。

Objective To study relationship between integrins and carcinogenesis, development, treatment or prognosis of gastric cancer. Methods The literatures about integrins and gastric cancer in recent years were reviewed and analyzed. Results The current study found that the β1 subunit integrins and av subline integrins are closely associated with the gastric cancer. The β1 subunit integrins are associated with the invasion and metastasis of the gastric cancer, the cry subline integrins are associated with the typing, grading, and staging of the gastric cancer, and the avβ3, avβ5 and avβ6 are associated with the prognosis of the gastric cancer, further more, the avβ6 could be used as an independent effective prognostic factor. Conclusions Integrins are associated with occurrence, development, treatment, and prognosis of gastric cancer. It＇s mechanism such as signal transduction pathway is not completely clarified. With further in-depth research, it＇s molecular mechanism would be gradually elucidated and provide new ideas and methods for diagnosis, treatment, and prognosis of gastric cancer.