TSG-6在眼科疾病中的研究进展

Recent advances of TSG-6 in ophthalmic diseases

肿瘤坏死因子α刺激基因-6（tumor necrosis factoro α stimulatedgene6，TSG-6）编码的分泌性蛋白是一种保护性的炎症反应因子，它通过与透明质酸、硫酸软骨素或蛋白多糖结合，介导炎症细胞迁移、黏附，参与免疫调节和细胞外基质重塑，进而发挥炎症调控作用。重组TSG-6蛋白已应用于多种疾病模型的研究，并表现出了广泛而强烈的抗炎作用。最近的研究发现，重组人TSG-6局部应用可减轻多种眼病的炎症反应和病理表现。近几年间充质干细胞在眼科疾病的研究和应用取得了突破性的进展，而TSG-6已被证明是间充质干细胞发挥作用的关键媒介。这提示TSG-6很可能成为眼病治疗的新靶点，有潜在的临床应用价值。

TSG-6 protein is a protective inflammatory factor, which plays the role of anti-inflamma- tory by binding to hyaluronic acid, chondroitin sulfate, or proteoglycan to mediate inflammatory cell migra- tion and adhesion, and then participate the immune regulation and extraeellular matrix remodeling. Recombi- nant TSG-6 protein has been applied to a variety of disease models, and has shown a broad and strong inhibition of inflammation. Recent studies have found that TSG-6 not only can directly ameliorate the pathologic manifestation of various ophthalmic diseases, but also can act as the media of the stem cells to inhibit inflam- matory responses. This suggests that TSG-6 may be a therapeutic target for ophthalmic diseases, with a po- tential clinical value for clinical application.