摘要
标题化合物是一个重要的药物中间体。以2-氨基-5-氯吡啶为起始原料,经溴代和重氮化反应得到目标化合物,总收率为66.31%,其结构经~1HNMR、^(13)CNMR和MS确定。该方法具有成本低廉、操作简单且收率较高等优点,符合工业化生产的要求。
In this work,2-amino-5-chloropyridine as the starting material,the important intermediate of 2-iodo-3-bromo-5-chloropyridine was prepared by bromination and diazotization.The structure was confirmed by 1^HNMR,13^CNMR and MS.The process is low cost,manipulation easily,high yield,and suitable for industrial production.The total product yield was 66. 31%.
出处
《化学试剂》
北大核心
2017年第9期1021-1022,共2页
Chemical Reagents
基金
贵州省科技厅社发公关项目(黔科合SY字[2014]3054)
