药用植物活性成分调控p65核转运总结与展望

Summary and prospect of medicinal plant active substances in regulation of p65 nuclear translocation

NF-κB作为细胞内最重要的核转录因子,参与许多细胞内信号通路的传导以及遗传信息的转录与调控,其信号传导通路主要包括IκB激酶的活化、IκB蛋白降解以及p65的核转运,其中p65核转运结合DNA是NF-κB发挥作用的关键。NF-κB的异常激活是诱发氧化应激、炎症、癌症等的主要因素,因此维持NF-κB活性平衡和调控p65的核转运对相关课题的深入研究具有重要的参考意义。该文综述了药用植物中主要活性物质多酚类、皂苷类、生物碱等对p6 5核转运的调控作用并对NF-κB上游通路进行了讨论,以期为天然活性物质开发成功能性食品的研究提供参考价值。

As the most important nuclear transcription factors in the cells,NF-κB is involved in many intracellular signaling pathways and transcription and regulation of genetic information. The signal transduction pathways mainly include the activation of IκB kinase,degradation of IκB protein and the nuclear translocation of p65. p65 trans-nuclear binding with DNA is the key for NF-κB to play a role. Abnormal activation of NF-κB is a major factor in the induction of oxidative stress,inflammation,cancer and so on. Therefore,maintaining the balance of NF-κB activity and regulating the nuclear translocation of p65 have great significance for further research on related subjects. In this paper,the regulation effects of the main active substances of medicinal plants（ such as polyphenols,saponins,and alkaloids） on p65 nuclear translocation and the upstream pathway of NF-κB were discussed,expecting to provide reference for the development of natural active substances for functional food.