环磷酰胺冲击治疗儿童难治性肾病的临床分析

Clinical analysis of cyclophosphamide shock treatment in children with refractory nephropathy

目的探讨大剂量环磷酰胺(cyclophosphamide,CTX)冲击治疗儿童难治性肾病(refractorynephrotic syndrome,RNS)的临床疗效及不良反应。方法选取2006年8月至2016年8月期间收治的采用大剂量CTX冲击治疗RNS患儿102例,对其临床资料及随访情况进行回顾性统计分析。结果治疗后各项生化指标均较前明显好转,差异有统计学意义(P<0.05);完全缓解56例,部分缓解21例,总体有效率为75.5%,不良反应发生率为19.6%;不同临床分型的缓解率无明显差异。结论大剂量CTX冲击治疗儿童难治性肾病疗效肯定,不良反应较少。

Objective To investigate the effect and adverse reactions of intravenous cyclophosphamide （CTX） pulse therapy on refractory nephrotic syndrome （RNS） in children. Methods Retrospective study was carried on 102 patients with RNS treated with high dose CTX impact treatment in The First Hospital Affiliated to Guangxi Medical University from August 2006 to August 2016. Clinical data and follow-up records were analyzed. Results Biochemical indicators significantly improved after treatment, and the difference was statistically significant （P 〈 0.05）. Fifty-six patients achieved complete remission, and 21 patients achieved partial remission, with an effective percentage of 75.5%, and adverse drug reactions incidence rate of 19.6%. There was not significant difference in the remission rate of different clinical types. Conclusions High dose of CTX shock treatment on children refractory nephrotic syndrome is effective, with low adverse reactions incidence.