达克罗宁复合丙泊酚用于无痛胃镜检查的临床效果

Assessment of the clinical effect of dyclonine combined with propofol in the application of painless gastroscopy

目的探讨达克罗宁复合丙泊酚用于无痛胃镜检查中的安全性和可行性。方法选择2016年9-12月在我院行无痛胃镜检查的90例患者,按随机数字表法分为3组:达克罗宁+丙泊酚组(DP组)、芬太尼+丙泊酚组(FP组)、丙泊酚组(P组),每组各30例。观察并记录3组患者检查前、中、后的血流动力学变化,不良反应,丙泊酚用量,检查及苏醒时间。结果 DP组与FP组在高血压、心动过速、呛咳、体动的发生率,以及丙泊酚用量显著低于P组(P<0.05),FP组和P组在呼吸抑制发生率、检查及苏醒时间显著高于DP组(P<0.01),DP组和P组在恶心呕吐发生率显著低于FP组(P<0.05)。结论达克罗宁复合丙泊酚用于无痛胃镜检查,降低了检查时心血管反应、呛咳、体动、呼吸抑制、恶心呕吐等不良反应的发生率,减少了丙泊酚用量,缩短了检查和苏醒时间。因此,达克罗宁复合丙泊酚用于无痛胃镜检查是一种更加安全可行的麻醉方案。

Objective To investigate the safety and feasibility of dyclonine combined with propofol in the application of painless gastroscopy. Methods A total of 90 patients received the painless gastroscopy in our hospi- tal were enrolled from September to December 2016. They were divided into 3 groups according to the random number table （n = 30）： Dyclonine＋propofol （DP） group, Fentanyl＋propofol （FP）group, Propofol （P） group. The hemodynamic changes, adverse reaction, propofol dosage, time of gastroscopy examination and time of conscious recovery were observed and recorded. Results Compared with P group, the incidence of hypertension, tachycardia, choking cough, body movement and the dosage of propofol in DP group and FP group were significantly decreased （P 〈 0.05, respectively ）. Compared with DP group, the incidence of respiratory depression, the time of gastroscopy examination and the time of Conscious recovery in FP group and P group were significantly increased （P 〈 0.01, respectively）. Compared with FP group, the incidence of nausea and vomiting in DP and P group were significantly decreased （P 〈 0.05, respectively ）. Conclusions Dyclonine combined with propofol reduced the incidence of cardiovascular response, choking cough, body movement, respiratory depression, and nausea and vomiting, with the reduced dosage of propofol, the shorten gastroscopy examination time and the recovery time. Therefore, dyclonine combined with propofol is a safe and feasible anaesthesia management for the painless gastroscopy.