奥拉西坦对脑卒中患者近期认知功能障碍的改善效果

Improvement effect of oxiracetam on stroke patients with recent cognitive dysfunction

目的 探讨奥拉西坦对脑卒中患者近期认知功能障碍的改善效果。 方法 将180例脑卒中后认知功能障碍患者按照随机数字表法分为两组，每组90例。对照组给予吡拉西坦治疗，观察组给予奥拉西坦治疗，治疗后6个月比较两组患者的日常生活能力量表（ADL）、简易智能量表（MMSE）和蒙特利尔认知评估量表（MoCA）评分及不良反应。 结果 治疗后6个月，观察组MoCA、MMSE评分均高于对照组，ADL评分低于对照组，差异均有统计学意义（P〈0.05）；治疗后3、6个月，观察组MoCA评分改善总有效率分别为81.11%和93.33%，MMSE评分改善总有效率分别为76.67%和83.33%，ADL评分改善总有效率分别为80.00%和94.44%，均高于对照组，差异均有统计学意义（P〈0.05）。两组不良反应发生率比较差异未见统计学意义（P〉0.05）。 结论 奥拉西坦可提高脑卒中患者近期认知功能和日常生活能力，随着用药时间延长其改善效果更加明显，且未见明显不良反应。

Objective To inveetigate the improvement effect of oxiracetamon on recent cognitive dysfunction in patients with stroke. Methods A total of 180 stroke patients with cognitive dysfunction were divided into observation group and control group according to the random number table, with 40 ea- ses in each group. Patients in the control group were treated with Laci 5taw, patients in the observation group were treated with oxiracetam, after 6 months of treatment, daily life ability scale （ ADL）, simple intelligence scale （MMSE）, montreal cognitive assessment scale （MoCA） score and adverse reaction were compared between the two groups. Results After 6 months of treatment, the MMSE and MoCA scores in the observation group were higher than those in the control group, and the ADL score was lower than that in the control group, the differences were significant （ P 〈 0. 05 ） ; after 3, 6 months of treat- ment, the improvement of MoCA score in the observation group respectively was 81.11% and 93.33%, the improvement of MMSE respectively was 76. 67% and 83.33%, the improvement of ADL respectively was 80. 00% and 94. 44% , which were higher than those in the control group, the differences were sig- nificant （ P 〈 0.05 ） ; there was no difference in the incidence of adverse reactions between the two groups （ P 〉 0. 05 ）. Conclusions Oxiraeetam can significantly improve the recent cognitive function and ability of daily life of patients with stroke, with the prolongation of treatment, the improved effect will be more marked, without definite adverse reactions.