丹参川芎嗪联合厄贝沙坦对高血压患者血管内皮功能的影响

Effect of Danshen ligustrazine combined with irbesartan on vascular endothelial function in pa- tients with hypertension

目的 探讨丹参川芎嗪联合厄贝沙坦对高血压患者血管内皮功能的影响。 方法 将124例高血压患者按随机数字表法分为观察组及对照组，每组62例，对照组给予口服厄贝沙坦10 mg/d治疗，观察组在对照组基础上应用丹参川芎嗪治疗，持续治疗8周，对比分析两组患者治疗前后血压、血脂水平及血管功能情况。 结果 观察组治疗后收缩压（SBP）、舒张压（DBP）、内皮素（ET）水平低于对照组（P〈0.05），而内皮依赖性舒张功能（FMD）、一氧化氮（NO）、内皮型NO合成酶（eNOS）高于对照组，差异有统计学意义（P〈0.05）。随访1年，观察组心肌梗死、心律失常、心力衰竭、脑卒中等心脑血管疾病发生率低于对照组（P〈0.05）。 结论 丹参川芎嗪联合厄贝沙坦能有效降低高血压患者血压水平，改善患者血管内皮功能及炎症反应，降低患者心血管并发症发生风险。

Objective To investigate the effect of Danshen ligustrazine and irbesartan on vascu- lar endothelial function in patients with hypertension. Methods One hundred and twenty-four hyperten- sive patients were divided into observation group （ n = 62 ） and control group （ n = 62 ） by random table method. The control group were treated with irbesartan 10 mg/d, the observation group were treated with Danshen ligustrazine and irbesartan, and the treatment lasted for eight weeks. The blood pressure, blood lipid levels and vascular function of two groups before and after treatment were compared. Results The levels of SBP, DBP, endothelin （ET） of observation group were lower than those of the control group af- ter treatments （ P 〈 0. 05 ）. The levels of endothelium-dependent vasodilation （ FMD）, nitric oxide （ NO）, endothelial NO synthase （eNOS） of observation group were higher than those of the control group （ P 〈 0. 05 ）. The incidences of myocardial infarction, arrhythmias, heart failure, stroke and other cardiovas- cular and cerebrovascular disease of observation group were lower than those of the control group during one year follow-up （P 〈 0. 05 ）. Conclusions Danshen ligustrazine and irbesartan can effectively lower blood pressure in hypertensive patients, improve vascular endothelial function and inflammation, and re- duce the risk of cardiovascular complications.