新生儿外科感染性疾病病原菌分布与耐药性

Pathogens distribution and drug resistance of neonatal surgical patients infections

目的了解新生儿外科感染性疾病的病原菌分布与耐药情况,为合理用药提供依据。方法采用回顾性调查方法,对湖北省某医院509例住院新生儿外科感染性疾病患儿送检病原学标本进行检测和分析。结果从509例患儿送检标本中检出致病菌阳性402例,阳性率78.98%;感染病种以肛周脓肿和脐炎居多,占68.4%。检出致病菌居前3位的分别为金黄色葡萄球菌、大肠埃希菌和肺炎克雷伯菌。金黄色葡萄球菌对青霉素G和氨苄西林耐药率为100%;对阿莫西林/克拉维酸、头孢西丁、克林霉素、苯唑西林和红霉素耐药率均接近40%。大肠埃希菌和肺炎克雷伯菌对氨苄西林耐药率最高,对其他种类抗菌药物均不同程度耐药。结论该医院新生儿外科感染性疾病的致病菌以金黄色葡萄球菌、大肠埃希菌和肺炎克雷伯菌为主,应依据药敏试验结果合理使用抗菌药物。

Objective To study the pathogens distribution and drug resistance of infections in neonatal surgical patients,so as to provide the basis for clinical use of antibiotics. Methods 509 cases of pus specimens of infections in neonatal surgical patients were tested and analyzed by bacterial culture and drug sensitivity test. Results 402 case of pathogens were detected from 509 cases of bacterial samples,the positive rate was 78. 98%,the most infection disease were perianal abscess and omphalitis,and the infectious nate was 68. 4%. The top three pathogens were Staphylococcus aureus、Escherichia coli and Klebsiella pneumoniae. The resistance rates of Staphylococcus aureus to penicillin G and ampicillin were 100%,to amoxicillin/clavulanic acid、cefoxitin、clindamycin、oxacillin and erycin were nearly 40%. Escherichia coli and Klebsiella pneumoniae had the highest resistance rates to ampicillin,but had different resistance rates to other kinds of antibiotics. Conclusion The pathogens of neonatal surgery infections were mainly Staphylococcus aureu、Escherichia coli and Klebsiella pneumonia.Antibiotics should be used reasonable based on the results of drug sensitivity tests.