OCT评估垂体瘤患者视功能改变的临床应用及进展

Clinical application of optical coherence tomography for evaluating visual function in patients with pituitary tumor

垂体瘤因其位置的特殊性,会导致患者视野缺损、视力下降及眼底改变.其与视交叉是否接触及压迫的位置不同,可导致不同的视功能损害.与垂体瘤相关的视功能检查包括视野、相干光断层扫描（optical coherence tomography,OCT）以及视觉诱发电位等.经OCT测量,垂体瘤患者视乳头旁视网膜纤维层厚度以及黄斑区神经节细胞复合体厚度均较正常对照者变薄,且变薄程度与术后视野恢复程度呈负相关.此外,OCT相关指标测量简便、结果客观、可定量,其临床应用越来越为人们所关注.

Pituitary tumor is a kind of benign tumor which originates from epithelium of adenohypophysis,the patients of which have different degerees of visual field loss and visual acuity decrease,and corresponding fundus changes because of the specificity of its location.The visual function damage will vary a lot due to the position of the tumor.Ocular examinations that are relevant to pituitary tumor patients include visual field（VF） test,optical coherence tomography（OCT）,visual evoked potential（VEP） and so on,with the former two uesed more.The thickness of parapapillary retinal nerve fiber layer （RNFL） and macular ganglion cells complex（GCC） in pituitary patient become thiner than healthy group,and the degree of the two changes are relative to the visual function recovery.Besides,OCT tests are becoming much more focused because its convenience and objectivity.We aimed at comparing the reports on this published in recent years,and focused on how the visual function examination works in detecting the change of the visual function in pituitary tumor patients.