三七叶中的新三萜皂苷

New triterpenoid saponins from the leaves of Panax notoginseng

采用HPD100大孔树脂、硅藻土、硅胶、ODS制备色谱等色谱分离方法,从三七叶中分离得到5个化合物,通过光谱分析和化学方法对其进行结构鉴定,确定其分别为:3-O-β-D-glucopyranosyl-(1→2)-β-Dglucopyranosyl-12β,23(R)-epoxydammara-24-ene-3β,6α,20(S)-triol 20-O-α-L-arabinofuranosyl-(1→6)-β-D-glucopyranoside(1)、3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl-12β,23(R)-epoxydammara-24-ene-3β,6α,20(S)-triol 20-O-α-L-arabinopyranosyl-(1→6)-β-D-glucopyranoside(2)、notoginsenoside FP2(3)、gypenosideⅨ(4)和ginsenoside Rg1(5)。其中,化合物1、2为新化合物,分别命名为notoginsenoside Fh8、notoginsenoside Fh9。

Five triterpene saponins were isolated from the aqueous extract of the leaves of Panax notoginseng（Burk.） F.H.Chen via various chromatographic approaches, including HPD-100 macroporous resin, silica gel, reverse phase C18 and so on. Spectroscopic and chemical methods were used to elucidated their structures, which were determined to be 3-O-β-D-glucopyranosyl-（1→2）-β-D-glucopyranosyl-12β,23（R）-epoxydammara-24-ene-3β,6α,20（S）-triol 20-O-α-L-arabinofuranosyl-（1→6）-β-D-glucopyranoside（1）, 3-O-β-D-glucopyranosyl-（1→2）-β-D-glucopyranosyl-12β,23（R）-epoxydammara-24-ene-3β,6α,20（S）-triol 20-O-α-L-arabinopyranosyl-（1→6）-β-D-glucopyranoside（2）, notoginsenoside FP2（3）, gypenoside Ⅸ（4）, ginsenoside Rg1（5）. Compounds 1 and 2 are new compounds and named as notoginsenoside Fh8 and notoginsenoside Fh9.