二膦酸盐在儿童骨质疏松中临床应用及安全性

Use and safety of bisphosphonates in pediatric osteoporosis

二膦酸盐(BPs)类药物是成人骨科常用的抗骨吸收经典药物。近年来,BPs在儿童骨质疏松中的应用越发广泛,研究显示,BPs可安全有效地增加骨密度、降低骨折率。然而,考虑到BPs在成人患者中出现的不良反应,其对患儿的潜在影响仍需观察。目前,BPs在儿童中的用药指征仍未明确,患儿用药期间要密切随访。该文讨论了BPs在儿童中的最新应用进展,介绍了已经被报道的临床常规治疗方案和建议,并就常见和潜在的不良影响进行讨论。

Bisphosphonates are one of classical drugs in orthopaedics department used for prevention of bone resorption in adulthood. In recent years, bisphosphonates have been increasingly used in pediatric patients for the treatment of osteoporosis, and studies have shown the safety and effective result of BPs in increasing bone density and reduce the rate of fracture. However, considering adverse reactions of BPs in adult patients, the potential consequences in children still should be monitored. The current well-defined criteria for the use of BPs in pediatrics are still not clear, and the children will still need to be closely followed up. This review focused on the latest advances of bisphosphonate treatment in pediatric patients, introducing some of the clinical general measures and recommendations that have been reported, and discussing the common and potential adverse effects.