慢性病治疗功能评估疲劳量表与系统性红斑狼疮的关系及影响因素

The application and influence factors of FACIT Fatigue Scale in SLE patients

目的应用慢性病治疗功能评估（FACIT）疲劳量表对系统性红斑狼疮（SLE）患者进行疲劳评价，探讨FACIT疲劳量表与SLE的关系及其影响因素。方法选取哈尔滨医科大学附属第一医院风湿免疫科就诊的223例中国汉族SLE患者，对其记录FACIT疲劳量表调查问卷进行的疲劳评价，同时记录患者的一般信息及实验室检测指标，同时记录健康调查简表（SF-36）调查问卷及SLE疾病活动指数（SLEDAI）积分表进行的生活质量和疾病活动度的评价。结果SLE患者FACIT疲劳量表积分与SF-36各维度呈负相关（P〈0．05）。与小学及以下学历的SLE患者相比，中学和大学及以上学历的SLE患者FACIT疲劳量表积分降低（P〈0．05）。与红细胞沉降率（ESR）正常组SLE患者相比，ESR升高组SLE患者FACIT疲劳量表积分升高（P〈0．05）。与补体C3正常组SLE患者相比，补体C3减低组SLE患者FACIT积分升高（P〈0．05）。SLE患者FACIT疲劳量表积分与SLEDAI积分、年龄、ESR呈正相关（P〈0．05）。SLE患者FACIT疲劳量表的独立影响因素为躯体疼痛、精神健康、补体C3。结论SLE患者的FACIT疲劳量表积分与疾病活动度、生活质量等因素相关。因此，降低SLE患者的疾病活动度，改善生活质量可能有助于减轻SLE患者的疲劳。

Objective To evaluate the application and influence factors of the Functional Assessment of Chronic Illness Therapy （FACIT-Fatigue） scale in patients with systemic lupus erythematosus （SLE）. Methods SF-36 questionnaires were used to estimate the health-related quality of life （HRQOL） of SLE patients in Chinese Hun population. FACIT-Fatigue scale was applied to measure fatigue. Disease activity was determined by SLE disease activity index （SLEDAI） , meanwhile demographic parameters such as gender, disease duration, etc. were recorded. Results A total of 223 patients with SLE were enrolled in the survey. FACIT-Fatigue scale was negatively correlated with SF-36 （ P 〈 0.05 ）. FACIT-Fatigue scale of patients with SLE were correlated with education, erythrocyte sedimentation rate （ESR）, C3, and SLEDAI score （ P 〈 0. 05 ）. The degree of bodily pain, the status of mental health and the amount of complement C3 were the independent factors of FACIT-Fatigue （P 〈 0. 1 ）. Conclusion FACIT-Fatigue scale is related to disease activity, quality of life, age and ESR in patients with SLE. There fore, reduce the disease activity and improve the quality of life of SLE patients may be helpful to reduce the fatigue of patients with SLE.