摘要
AIM：To quantify the association between diabetes and glaucoma using Meta-analysis.METHODS：Pub Med and Embase were searched using medical subject headings and key words related to diabetes and glaucoma.The inclusion criteria were：1）the study design was a prospective cohort study;2）the exposure of interest was diabetes;3）the outcome of interest was primary open angle glaucoma（POAG）;4）risk ratios（RR）and the corresponding 95%confidence interval（CI）.Data were pooled using fixed effects models to take into account heterogeneity between studies.Seven prospective studies were selected.Diabetes increased the incidence of glaucoma by 36%（OR=1.36,95%CI=1.25-1.50）.There was no evidence of statistical heterogeneity（I2=0,P=0.53）or publication bias（the funnel plot did not identify obvious asymmetry）.RESULTS：Seven prospective cohort studies were incorporated in this Meta-analysis.The pooled RR of the association between POAG and diabetes based on the risk estimates of the seven cohort studies was 1.36（95%CI=1.24-1.50）,with no significant heterogeneity across studies（I2=0;P=0.526）.The sensitivity analysis yielded a range of RRs from 1.34（95%CI=1.22-1.48）to1.40（95%CI=1.18-1.67）.CONCLUSION：Diabetes is associated with a significantly increased risk of glaucoma.
AIM：To quantify the association between diabetes and glaucoma using Meta-analysis.METHODS：Pub Med and Embase were searched using medical subject headings and key words related to diabetes and glaucoma.The inclusion criteria were：1）the study design was a prospective cohort study;2）the exposure of interest was diabetes;3）the outcome of interest was primary open angle glaucoma（POAG）;4）risk ratios（RR）and the corresponding 95%confidence interval（CI）.Data were pooled using fixed effects models to take into account heterogeneity between studies.Seven prospective studies were selected.Diabetes increased the incidence of glaucoma by 36%（OR=1.36,95%CI=1.25-1.50）.There was no evidence of statistical heterogeneity（I2=0,P=0.53）or publication bias（the funnel plot did not identify obvious asymmetry）.RESULTS：Seven prospective cohort studies were incorporated in this Meta-analysis.The pooled RR of the association between POAG and diabetes based on the risk estimates of the seven cohort studies was 1.36（95%CI=1.24-1.50）,with no significant heterogeneity across studies（I2=0;P=0.526）.The sensitivity analysis yielded a range of RRs from 1.34（95%CI=1.22-1.48）to1.40（95%CI=1.18-1.67）.CONCLUSION：Diabetes is associated with a significantly increased risk of glaucoma.
基金
Supported by the Plan of Wenzhou Science and Technology(No.Y20160439)
