舒血宁注射液治疗急性胰腺炎的临床疗效及其对氧化应激反应的影响

Curative effect of Shuxuening injection for patients with acute pancreatitis and which influence on the oxidative stress

目的探讨舒血宁注射液治疗急性胰腺炎的临床疗效及其对氧化应激反应的影响。方法选择2013年12月—2016年11月在驻马店市中医院进行治疗的急性胰腺炎患者150例,随机分为两组,对照组65例患者,接受常规治疗,观察组85例患者,在对照组基础上接受舒血宁注射液治疗,每天1次,两组患者均连续治疗20 d。评价并比较两组患者治疗的临床疗效,分别检测两组患者治疗前后的炎症因子及氧化应激因子的含量并比较分析;通过APACHEⅡ以及BISAP评分量表评价两组患者治疗前后的胰腺损伤程度。结果观察组的总有效率为91.8%,显著高于对照组的80.0%,差异有统计学意义(P<0.05)。经治疗后,两组患者肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)以及丙二醛(MDA)较治疗前均显著降低,组内比较差异有统计学意义(P<0.05);且观察组显著低于对照组,差异有统计学意义(P<0.05)。两组患者超氧化物歧化酶(SOD)较治疗前显著升高,差异有统计学意义(P<0.05);且观察组明显高于对照组,差异有统计学意义(P<0.05)。两组患者经治疗后APACHEⅡ以及BISAP评分较治疗前均显著降低,差异有统计学意义(P<0.05);且观察组显著低于对照组,差异有统计学意义(P<0.05)。结论舒血宁注射液用于治疗急性胰腺炎可显著降低机体的炎性以及氧化应激反应,提高临床疗效,值得临床推广应用。

Objective To explore the curative effect of Shuxuening injection for patients with acute pancreatitis and which influence on the oxidative stress. Methods 150 patients with acute pancreatitis were enrolled in our hospital from December 2013 to November 2016, of which patients divided into two groups randomly, control group （n = 65） accepted conventional therapy, and study group （n = 85） adopted Shuxuening injection based on the treatment of control group. The curative effect of two groups were evaluated, and the factors of inflammatory and oxidative stress response were detected responsibly before and after treatment, the pancreatic injury degree were evaluated via the gauge of APACHE II and BISAP. Results The total effective rate of study group for curative effect was higher significantly than those patients in control group （P 〈 0.05）; After treatment, the tumor necrosis factor a （TNF-a）, interleukin -6 （IL-6） and malondialdehyde （MDA） of two groups decreased significantly compared with before treatment （P 〈 0.05）, and the level of which factors in study group were lower than those control group, and which difference was significance （P 〈 0.05）, the superoxide dismutase （SOD） of all patients increased significantly compared with before treatment （P 〈 0.05）, and SOD level of patients in study group was higher than those patients in control group （P 〈 0.05）; the APACHE II and BISAP score of all patients went down remarkably compared with before treatment （P 〈 0.05）, and which score of patients in study group was lower than that control group, and which difference was significance （P 〈 0.05）. Conclusions Shuxuening Injection for patients with acute pancreatitis deserved popularization in clinic, which not only decreased the inflammatory and oxidative stress response significantly, but also increased the curative effect remarkably.