Xp11.2易位/TFE3基因融合相关性肾癌的CT表现

CT Features of Renal Cell Carcinoma Associated with XP11.2 Translocation/TFE Gene Fusion

目的分析Xp11.2易位/TFE3基因融合相关性肾癌(renal cell carcinoma associated with XP11.2translocation/TFE gene fusion,Xp11.2/TFE RCC)的CT影像特点,提高诊断水平。方法回顾性分析7例Xp11.2易位性肾癌的CT资料,观察肿瘤的部位、大小、形态、密度、强化程度、包膜、肾周组织侵犯及淋巴结转移等特点。结果平扫6例呈稍高密度,1例稍低密度;3例瘤体内见大片出血及坏死,5例可见点状钙化;增强扫描肿瘤皮质期中等强化,髓质期强化程度最高,肾盂期逐渐下降且低于皮质期的强化程度,皮质期及髓质期强化程度均低于肾皮质而高于肾髓质,肾盂期强化低于肾髓质。结论 Xp11.2易位性肾癌CT扫描有一定的特征性表现,有助于与其他肾癌亚型鉴别。

Objective To investigate the CT image features of renal cell carcinoma associated with XP11.2 translocation/TFE gene filsion （Xp11.2/TFE RCC） and improve the accuracy of diagnosis.Methods CT data of seven cases Xp11.2/TFE RCC were analyzed retrospectively, the tumors＇locations, sizes, shapes, densities, enhancement degrees, envelopes, perirenal tissue invasions and lymphatic metastasis, and other features, were observed respectively. Results plain scans in 6 cases showed slightly high density and one case showed stightly hypodeme in tumor, 3 cases showed extensive hemorrhage and necrosis in interior of the tumor and 5 cases showed calcification dots within it.In enhanced scans, all the cases showed moderate enhancement in renal cortex phase, the enhance degree of corticomedullary phase was the highest and excretory phase was lowest among cortex phase scans. Furthermore, the enhance degree of renal cortex phase and corticomedullary phase were both inferior to the renal cortex and exceeded in medulla kidney. The enhance degree of excretory phase was lower than medulla kidney. Conclusion Xp11.2/TFE RCC has certain CT characteristics which is conductive to identify subtypes of other renal cell carcinoma.