人工关节假体感染诊治的研究进展

Research progress in diagnosis and treatment of prosthetic joint infection

人工关节假体感染(PJI)是关节置换术后灾难性的并发症。PJI的危险因素包括免疫缺陷,肥胖,糖尿病等。PJI的临床诊断仍是一个挑战,主要方法包括组织培养,血清标记物,组织病理和滑液穿刺分析等。PJI的治疗方法包括单纯药物治疗;清创保留关节假体;一期翻修;二期翻修等。PJI的致病机理主要在于早期细菌生物膜的形成以及假体/组织界面宿主免疫能力的缺乏。本专栏聚焦PJI的预防、诊断和治疗,介绍国内外学者在该领域所开展的卓有成效的研究,以促进PJI诊治工作进一步的发展。

Prosthetic joint infection（ PJI） is a disastrous complication after the arthroplasty. The risk factors of PJI include immunodeficiency,obesity,diabetes,ect. The clinical diagnosis of PJI is still a challenge and the methods mainly include tissue culture,serum markers,histopathology and synovial puncture analysis. The therapeutic measures of PJI include simple antibiotic therapy; debridement and the retention of joint prosthesis; one-stage revision; two-stage revision and so on. The pathogenesis of PJI is mainly due to the formation of early bacterial biofilm and the lack of host immunity in the prosthesis-tissue interface. This column focused on the prevention,diagnosis and treatment of PJI,and introduced the outstanding researches conducted by the scholars at home and abroad,in order to promote the further development of PJI diagnosis and treatment.