西咪替丁应用的安全性研究进展

Research progress on application safety of Cimetidine

西咪替丁作为H_2受体拮抗剂,除用于治疗消化性溃疡外,在临床中具有许多新的药理作用及用途。由于西咪替丁显著的疗效和良好的安全性,该药的临床应用越来越广泛,处方量与日俱增。但是近年来许多报道表明西咪替丁可引发各种不良反应,包括神经系统、生殖系统、变态反应、心血管系统、泌尿系统、内分泌系统不良反应以及药物相互作用禁忌等。有的不良反应发生率较高,但对于一些潜在的、罕见的药物不良反应也应引起高度重视。本文对西咪替丁安全性及其不良反应的研究进展进行综述,为提高西咪替丁药物的临床疗效及安全性提供依据。

The H2-receptor antagonist Cimetidine, an antiulcer drug, has many new pharmacologic actions and clinical applications. Due to its notable curative effect and good safety, Cimitidine is increasingly applied in clinic and its prescriptions is growing. But in recent years the studies have shown that Cimetidine has the possibility of leading to adverse reactions in several aspects, such as in nervous system, reproductive system, anaphylaxis, cardiovascular system, urinary system, endocrinium and drug interactions. All these adverse reactions include not only some high incidence adverse reactions, but also some potential or rare ones. This article reviews the research progress on the safety of cimetidine and its adverse effects, in order to improve therapeutic effect and safety of clinical medications.