益气活血胶囊的成型工艺研究

Study on the Molding Process of Yiqi Huoxue Capsule

目的完善优化益气活血胶囊的制备工艺。方法按照现代制剂工艺制备方法 ,通过测定休止角、吸湿度、堆密度等选择合适的辅料并确定辅料配伍比例,选择填充的胶囊型号,完成制剂工艺设计。结果选择以主药乳糖:微粉硅胶(15∶2∶1)为配方,制成颗粒,选用0号胶囊装量0.37 g。结论设计的本胶囊制剂成型工艺,经3批生产具有较好的稳定性,可为下一步研究及新药开发奠定基础。

Objective： To optimize the preparation process of Yiqi Huoxue Capsule. Methods： In accordance with the preparation process of modern preparation technology,the appropriate excipients were selected by determining the angle of repose,the moisture absorption and the bulk density,and the proportion of excipients was determined. The capsule model was selected to complete the preparation process design. Results： The proportion of the main drug,lactose and gum arabic was 15∶2∶1,as a formula,which was made into particles. Capsule No. 0 was selected and the volume was 0.37 g. Conclusion： The preparation process of the capsule prepared by the 3 batch has good stability and can lay the foundation for further research and new drug development.