依达拉奉治疗1,2-二氯乙烷中毒性脑病的疗效观察

Treatment of toxic encephalopathy caused by 1,2-dichloroethane with edaravone

[目的]观察依达拉奉治疗1,2-二氯乙烷中毒性脑病的有效性和安全性。[方法]选择38例1,2-二氯乙烷中毒性脑病患者,随机分为依达拉奉治疗组和常规治疗组,治疗组在常规对症治疗的基础上,添加依达拉奉治疗,共治疗2周。对2组患者在治疗前后分别行Glasgow昏迷量表、改良Barthel指数、简易精神状态量表评估,以评定患者病情严重程度,并判断临床疗效。[结果]治疗后治疗组Glasgow昏迷量表、改良Barthel指数、简易精神状态量表评分优于对照组,差异均有统计学意义(P<0.01)。治疗组临床有效率为85.0%,高于对照组的55.6%,差异有统计学意义(P<0.05)。2组患者均未发生严重不良反应。[结论]依达拉奉治疗1,2-二氯乙烷中毒性脑病有效且安全,可促进患者神经功能恢复,改善认知能力及生活质量,提高临床疗效。

[Objective] To observe the clinical efficacy and safety of edaravone in the treatment of patients with toxic encephalopathy caused by 1,2-dichloroethane. [Methods] A total of 38 patients with toxic encephalopathy caused by 1,2- dichloroethane were randomly divided into 2 groups, i.e. edaravone treatment group and routine group. The symptomatic and supportive treatment were given to the patients in routine group, while edaravone was additionally given to the treatment group. After treatment for two weeks, the Glasgow Coma Scale, the Modified Barthel Index and Mini-Mental State Examination were used to assess the curative effectiveness of these two groups of patients. [Results] After treatment, the scores of Glasgow Coma Scale, Modified Barthel Index, Mini-Mental State Scale in the edaravone treatment group were better than those of routine group （P 〈 0.05）. Effective rate was 85.0% in the edaravone treatment group which was higher than that （55.6%） in the routine treatment group （P 〈 0.05）. [Conclusion] The edaravone is effective and safe in the treatment of toxic encephalopathy caused by 1,2 - dichloroethane.