益生菌对超重糖尿病患者糖脂代谢及氧化应激水平的影响

Effects of probiotics on glucose and lipid metabolism and oxidative stress in overweight patients with diabetes

目的观察益生菌对初发超重糖尿病患者血糖、血脂及氧化应激水平的影响,分析益生菌在糖尿病进程中的作用。方法选取初发超重糖尿病患者92例,按照随机数字表法分为研究组(46例)和对照组(46例),两组均给予饮食及运动指导,研究组加用功能益生菌制品每日1次。试验为期12周,治疗前后分别留取患者血标本检测血糖、血脂及氧化应激指标。结果两组患者糖脂及氧化应激水平较就诊前均有所改善,其中研究组空腹血糖(FBG)及三酰甘油(TG)水平均较治疗前明显降低;治疗后研究组的TG水平明显低于对照组水平(P<0.05)。研究组丙二醛水平较治疗前明显降低(P<0.05),超氧化物歧化酶水平均较对照组明显升高(P<0.05)。结论益生菌制品可帮助糖尿病患者更好的控制血糖、血脂及氧化应激水平。

Objective To observe the effect of probiotics on blood glucose, blood lipid and the level of oxida- tive stress in overweight patients with diabetes. Methods A total of 92 overweight patients with new onset type 2 diabe- tes mellitus were selected and randomly divided into experimental group and control group , and all of them got diet and exercise guidance. The experimental group was given probiotics once a day. The experiment lasted for twelve weeks. All patients were tested for blood glucose, blood lipid and oxidative stress before and after the experiment. Results Blood glucose and blood lipid of all the patients were lower than before. The FBG and TG of experimental group were obvious decreased than those before treatment , and the TG of experimental group was significantly lower than that of control group（P 〈0.05 ）. The MDA of experimental group was significantly lower than that before treatment （P 〈 0.05 ）, and the SOD of experimental group was obvious increased compared with the control group （P 〈 0.05）. Conclusin Probi- otics can help overweight patients with diabetes to reduce the level of blood glucose,blood lipid and oxidative stress.