肠道菌群与冠心病相关危险因素的研究进展

Research progress of gut microbiota and risk factors of coronary heart disease

肠道菌群不仅与炎症性消化道疾病、肿瘤、代谢性疾病等疾病相关,也与冠心病的发生、发展存在一定联系。肠道菌群主要通过短链脂肪酸(SCFA)、胆汁酸参与的多种代谢途径,内毒素分泌与循环以及多巴胺、肠上皮禁食诱导脂肪细胞因子(Fiaf)、磷酸腺苷活化蛋白激酶(AMPK)等多种细胞因子与生物活性酶影响高血压、肥胖、糖尿病、血脂异常等冠心病危险因素。通过粪便移植、益生菌、抗生素或饮食等方法调整菌群结构与功能可为冠心病的预防提供思路。

Gut microbiota is not only related to inflammatory digestive tract diseases, tumors, metabolic disea- ses, but also related to the occurrence and development of coronary heart disease. Gut microbiota affect hypertension, o- besity, diabetes, dyslipidemia and other risk factors of coronary heart disease mainly by the means of short chain fatty acids （SCFA） ,metabolic pathways involved in the bile acid, secretion and circulation of endotoxin, cytokines, such as dopamine ,fasting induced adipose factors （Fiaf） , bioactive enzymes, such as AMP-activated protein kinase （AMPK）. The structure and function of gut microbiota can be adjusted by fecal transplantation, probiotics, antibiotics or dietary habits, which can provide ideas for the prevention of coronary heart disease.