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动物宿主microRNAs抗病毒作用机制研究进展 被引量：2

Review of the Antiviral Mechanism of Animal Host MicroRNAs
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摘要 microRNAs(miRNAs)是一种长度为22nt的非编码RNA分子,能够结合mRNA,影响翻译效率,调控蛋白的表达。近来多项研究表明,动物宿主miRNAs通过多种机制抑制病毒的复制,如直接靶向病毒基因、干扰病毒复制所需因子、调节先天性免疫、调节细胞凋亡、调节细胞免疫,发挥抗病毒效应。本文归纳总结宿主miRNAs对病毒复制的调控机制,讨论miRNAs类抗病毒药物的应用情况,并展望该类药物的发展趋势。 MicroRNAs （miRNAs） are non-coding RNAs with a length of 22nt. miRNAs can regulate protein expression by binding specifically to mRNA and influencing translation efficiency. Recent studies have demonstrated that animal-host miRNAs can block virus replication and exert an antiviral effect through： direct binding to virus genes; targeting viral-replication factors; regulating innate immunity, apoptosis, and cellular immunity. In this review, we summarize the regulatory mechanisms of miRNAs on virus replication, discuss the development of miRNAs-based antiviral drugs, and overview the application of antiviral miRNAs in the future.
作者 樊晓旭 赵明 李林 吴晓东 王志亮
机构地区 中国动物卫生与流行病学中心 青岛市动物疫病预防控制中心
出处 《病毒学报》 CAS CSCD 北大核心 2017年第5期808-815,共8页 Chinese Journal of Virology
基金 “十三五”国家重点研发计划(项目号:2016YFD0500108),题目:小反刍兽疫病毒感染与免疫调控机制研究
关键词 MICRORNAS 动物 抗病毒 作用机制 MicroRNAs Animal Virus Mechanism
分类号 S852.65 [农业科学—基础兽医学]
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病毒学报
2017年 第5期

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