慢性肾脏病认知障碍的研究进展

The cognitive impairment in patients with chronic kidney disease

慢性肾脏病(CKD)患者普遍存在认知障碍,为患者带来诸多不良后果。尽管目前已有不少研究对CKD患者的认知障碍的机制进行探索,发现血管病变是最主要的机制之一,但仍需要更大样本、更多中心的研究及更长时间的随访来证实。临床医师应关注CKD患者的认知障碍,探寻可能的治疗手段,并进行针对性干预以改善患者的生活质量。

Cognitive impairment is common in patients with chronic kidney disease（ CKD） and is associated with worse survival. Although recent researches have suggested that vascular disease are one of the most important mechanisms,the pathogenesis of cognitive impairment in individuals with CKD remains elusive. Lager sample,more center and longer follow-ups are needed to convince it. Therefore,clinicians should be aware of the high rates of cognitive impairment that occur in all stages of CKD,explore possible preventive treatments and intervene pointedly to improve quality of life of these patients.